Bafuluomaidi as alpha No. subacceptor for blocking sympathetic nerve

A technology of buflomedil and uses, which is applied in the field of pharmacy of the first subtype receptor of alpha alpha, can solve the problems of no blood pressure lowering effect and the like

Inactive Publication Date: 2006-03-01
英属维尔京群岛福源集团有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, buflomedil has no significant blood pressure lowering effect (Vanhoutte PM. (1984) Cardiovascular pharmacology of buflomedil. Bibliotheca Cardiol.38: 209-221), and its reason and mechanism are still a mystery

Method used

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  • Bafuluomaidi as alpha No. subacceptor for blocking sympathetic nerve
  • Bafuluomaidi as alpha No. subacceptor for blocking sympathetic nerve
  • Bafuluomaidi as alpha No. subacceptor for blocking sympathetic nerve

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Experimental program
Comparison scheme
Effect test

Embodiment

[0013] experimental method

[0014] 1. Source of experimental animals

[0015] Male rats of the Wistar strain purchased from the Animal Center of the Faculty of Medicine, National Cheng Kung University, weighing about 200-250 g. Likewise, hypertensive rats (SHR) were also purchased from the center, aged over 8 weeks. Both kinds of mice were kept in the center, and the room temperature was maintained at 25±1°C with air conditioning, and the light time and dark time were 12 hours respectively, allowing the mice to eat and drink freely.

[0016] 2. The method of administration

[0017] "Buflo" (Buflo is a product launched by Xindong Chemical Industry Co., Ltd. with buflomedil as raw material) was dissolved in normal saline and force-fed to Stomach of mice: With the difference in animal weight, force-feed the drug solution of different volumes to maintain the required concentration (mg / kg), so as to meet the clinical usage.

[0018] 3. Detection of blood pressure changes in mi...

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Abstract

A medicine for relaxing the diseases caused by too much alpha1A-AR and prostatomegaly (B.P.H) is prepared from Bafuluomaidi.

Description

technical field [0001] The present invention relates to a first subtype receptor (α) that can block sympathetic nerves 1A -AR), especially with regard to an agent that can be used to ameliorate 1A - Drugs for diseases caused by excess AR. technical background [0002] The products currently on the market that use buflomedil as a raw material are mainly used for the treatment of peripheral vascular circulation disorders complicated by diabetes. Because buflomedil has vasodilation effect (Vanhoutte PM, Aarhus LL, Coen E, et al. (1983) Effects of buflomedil on theresponsiveness of canine vascular smooth muscle.J.Pharmacol.Exp.Ther.227:613-620) , Therefore, it is also used as a treatment for Raynaud's Phenomenon or intermittent claudication. [0003] Pharmacologically, buflomedil is a sympathetic receptor blocker (Toda N, Okunishi H, Okamura T, et al(1983) Effect of buflomedil on isolated dogarteries.Arch.Int.Pharmacodyn.et Therap.266 : 117-130), which can inhibit the alpha ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D207/04A61P13/08A61P25/00
Inventor 郑瑞棠
Owner 英属维尔京群岛福源集团有限公司
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