Bilobalide soft capsule and its preparation method

A technology of ginkgolide and soft capsule, applied in the field of ginkgolide A and soft capsule containing ginkgolide

Inactive Publication Date: 2006-09-27
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there have been many reports on the research on ginkgolides and their preparations in the prior art, the research on ginkgolides

Method used

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  • Bilobalide soft capsule and its preparation method
  • Bilobalide soft capsule and its preparation method
  • Bilobalide soft capsule and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Select raw materials according to the following proportions:

[0064] Ginkgolide 100g

[0065] Glycerin 18.0g

[0066] PEG 6000 6.0g

[0067] PEG 400 276.0g

[0068] Take PEG 400 Put 276.0g in a suitable container and add PEG 6000 6.0g, heated in a water bath until PEG6000 dissolves, stir well, add 18.0g glycerin, add 100.0g ginkgolide, grind into a uniform paste with a colloid mill, transfer to the storage tank of the soft capsule machine, and press it into a 0.3ml mold Soft capsules, made into 1000 soft capsules, about 0.4g in grain weight, shaped for 4 hours, washed with 95% ethanol to remove surface lubricants, etc., dried to equilibrium at 20-30% relative humidity at 28°C, taken out, and Inspection, packaging.

Embodiment 2

[0070] Select raw materials according to the following proportions:

[0071] Ginkgolide A 35.59g

[0072] Ginkgolide B 58.39g

[0073] Ginkgolide K 2.07g

[0074] Glycerin 18.0g

[0075] PEG 6000 6.0g

[0076] PEG 400 276.0g

[0077] Take PEG 400 Put 276.0g in a suitable container and add PEG 6000 6.0g, heated in a water bath until PEG6000 dissolves, stir well, add 18.0g glycerin, add ginkgolides A, B, K in total 96.05g, use a colloid mill to grind into a uniform paste, transfer to the storage barrel of the soft capsule machine, use 0.3ml mold is pressed into soft capsules, made into 1000 soft capsules, finalized for 4 hours, washed away surface lubricants etc. with 95% ethanol, dried to equilibrium at 20-30% relative humidity at 28°C, taken out, and Inspection, packaging.

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PUM

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Abstract

The present invention discloses a ginkgo lactone soft capsule. Said soft capsule contains 10-40% of total ginkgo lactone, in which it contains 3-16% of ginkgo lactone A, 5-26% of ginkgo lactone B and 0.01-4% of ginkgo lactone K. Besides, soft capsule also contains excipient glycerin, PEG 6000 and PEG 400.

Description

technical field [0001] The present invention relates to the preparation of ginkgolide, especially the soft capsule containing ginkgolide. K is a medicine made from an active ingredient, which belongs to the field of medicine. Background technique [0002] Ginkgolide is an effective substance extracted from the leaves of the Chinese herbal medicine Ginkgo biloba, which can be further subdivided into Ginkgolide A, B, C, and K structurally (Ginkgolide K is a Ginkgolide newly discovered by the inventor. ester monomer, another case application), etc., have had detailed bibliographical reports for the extraction method of ginkgolide, for example, people such as Li Xingang have introduced the laboratory extraction method of ginkgolide (referring to Li Xingang etc., ginkgolide in ginkgo leaf Laboratory extraction method research, China Pharmaceutical Industry Journal, 1998 No. 1), Chinese patent document CN1195665A has introduced the extraction method of ginkgolide and the preparat...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61K9/48A61P9/10
Inventor 萧伟楼凤昌戴翔翎凌娅王颖李明慧毕宇安
Owner JIANGSU KANION PHARMA CO LTD
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