Composition of ginkgo internal ester B and its preparation and use thereof

A technology of ginkgolide and compound, which is applied in the field of compound of ginkgolide B, can solve the problems of slow oral absorption, insoluble in water, low bioavailability, etc., and achieve the reduction of nuclear dissolution, good pharmacological activity, The effect of softening lesion reduction

Active Publication Date: 2004-02-04
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because ginkgolide B is difficult to separate and purify, insoluble in water, slow oral absorption, and low bioavailability, the developme

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0049] Example one.

[0050] A Ginkgolide B·Arginine complex. Prepare by the following method: take 2.5 g of arginine, add 1000 ml of water to dissolve, heat to 80°C, add 5 g of ginkgolide B that has been finely ground through an 80-mesh sieve, heat to dissolve, add 2.0 g of activated carbon for needles, stir and absorb at room temperature After 30 minutes, filter to remove charcoal, and the filtrate is spray-dried to obtain ginkgolide B·arginine complex.

Example Embodiment

[0051] Example two.

[0052] A Ginkgolide B·Arginine complex. Prepare by the following method: take 2.5 g of arginine, add 20 ml of ethanol to dissolve, heat to 60°C, add 5 g of ginkgolide B that has been finely ground through an 80 mesh sieve, stir to dissolve, filter, and concentrate the filtrate to dryness under reduced pressure. Get Ginkgolide B·Arginine Complex.

Example Embodiment

[0053] Example three.

[0054] A Ginkgolide B·Meglumine complex. Prepare by the following method: take 4 grams of meglumine, add 30ml of absolute ethanol to dissolve, heat to 50°C, add 10 grams of Ginkgolide B that has been finely ground through an 80 mesh sieve, filter, and concentrate the filtrate to dryness under reduced pressure to obtain Ginkgo biloba Lactone B·Meglumine complex.

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Abstract

A ginkgolide compounds B with changed physical properties of ginkgolide B and high stability and water-solubility can be mixed with pharmacologically receptable carrier to obtain a composition used to treat ischemic apoplexy.

Description

technical field [0001] The invention relates to a compound of ginkgolide B; its preparation method; and also relates to the application of the compound as an active ingredient in the treatment of ischemic stroke. Background technique [0002] Ginkgolide is an effective substance extracted from the Chinese herbal medicine Ginkgo biloba. The substance can be further subdivided into ginkgolide A, B, C, bilobalide, etc. in terms of structure. The extraction method of ginkgolide has been described in detail. Bibliographical reports, for example, people such as Li Xingang introduced the laboratory extraction method of ginkgolide (seeing Li Xingang etc., the laboratory extraction method research of ginkgolide in ginkgo leaf, Chinese Journal of Pharmaceutical Industry 1998 No. 1 issue), Chinese patent Document CN1195665A introduces the extraction method of ginkgolide and the preparation containing ginkgolide. The method is to extract ginkgo leaves by boiling wat...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/365A61P9/10C07D493/22
Inventor 肖伟戴翔翎凌娅李明慧尚强黄广伟毕宇安
Owner JIANGSU KANION PHARMA CO LTD
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