Application of elaifolin compound in preparation of neuroinflammation inhibition medicine

A technology of oleifolin and neuroinflammation, applied in the field of medicine, to achieve the effect of outstanding pharmacological activity

Pending Publication Date: 2022-05-17
INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This compound is a white powder with certain biological activities such as anti-gram-positive bacteria, anti-parasites, anti-tumor, immunosuppression, autophagy inhibition, anti-angiogenesis, etc. HY1 has not been used to inhibit neuroinflammation and related neurological diseases report

Method used

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  • Application of elaifolin compound in preparation of neuroinflammation inhibition medicine
  • Application of elaifolin compound in preparation of neuroinflammation inhibition medicine
  • Application of elaifolin compound in preparation of neuroinflammation inhibition medicine

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Experimental program
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Effect test

Embodiment Construction

[0045] Effect of HY1 on LPS-induced neuroinflammation in mouse cerebral cortex, hippocampus, striatum and cerebellum

[0046] 1. Experimental method

[0047] 1.1 Animal grouping and administration

[0048] Reagent LPS (Sigma Company); IL-1β, IL-6, TNFα, MCP-1 detection ELISA kit (Gitai Yikesai Biotechnology Co., Ltd.).

[0049] Experimental Animals Adult male BALB / c mice, weighing 20-22 g, were purchased from Speiford (Beijing) Biotechnology Co., Ltd., animal quality certificate number: SYXK (Beijing) 2016-0002. Raise under normal conditions, temperature (25±1°C), relative humidity 55%-65%, 12h photoperiod, free access to food and water.

[0050] Animal grouping and administration Animals were randomly divided into groups after 3 days of adaptation: normal control group (solvent control), LPS model group (LPS), HY1 3mg / kg administration group (LPS+HY1 3mg / kg), HY1 10mg / kg administration group (LPS+HY1-10 mg / kg). The solvent control group and the LPS model group were given ...

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Abstract

The invention belongs to the technical field of medicines, and discloses application of an elaiophylin compound HY1 in the aspect of inhibiting neuroinflammation. Specifically, the invention discloses application of the elaiophylin compound HY1 as shown in a formula (I) or pharmaceutically acceptable salt thereof in preparation of a medicine for inhibiting neuroinflammation and application of the elaiophylin compound HY1 in preparation of a medicine for preventing and / or treating acute and chronic central nervous system diseases caused by neuroinflammation, pharmacological experiments prove that the HY1 can significantly inhibit release of inflammatory factors interleukin-1beta (IL-1beta), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF alpha) and monocyte chemotactic factor MCP-1 in LPS-induced cerebral cortex, hippocampus, striatum and cerebellar tissues of a mouse, and has significant neuroinflammation inhibition activity.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to the preparation of an olive leaf compound HY1 for inhibiting neuroinflammation and related traumatic brain injury, cerebral apoplexy, Alzheimer's disease, Parkinson's disease, cerebellar atrophy, multiple sclerosis and Huntington's disease and other central nervous system diseases. Background technique [0002] Neuroinflammation is a complex cascade process that gradually develops, mainly manifested in the activation and proliferation of glial cells, the infiltration of peripheral inflammatory cells and the expression of related inflammatory cytokines. Neuroinflammation plays a key role in the pathogenesis of central nervous system diseases such as traumatic brain injury, stroke, Alzheimer's disease, Parkinson's disease, cerebellar atrophy, and Huntington's disease. Microglia are the immune cells of the central nervous system, and brain injury induces microglial activation and th...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P25/00A61P29/00A61P9/10A61P25/28A61P25/16A61P25/14
CPCA61K31/7048A61P25/00A61P29/00A61P9/10A61P25/28A61P25/16A61P25/14
Inventor 王月华杜冠华刘漫张姗姗刘冬妮杨滢霖
Owner INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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