Hedyotis caudatifolia anthraquinone compound and preparation method thereof

Abstract

The invention discloses a hedyotis caudatifolia anthraquinone compound and a preparation method thereof. The structural formula of the compound is shown in the specification. The preparation method of the compound comprises the following steps: (1) lixiviating hedyotis caudatifolia in a solvent, performing decompression concentration on the extract, and recovering the solvent until no alcohol taste exists; (2) adding water into the extract to dilute, then extracting with solvents petroleum ether, chloroform, ethyl acetate and n-butyl alcohol with polarities from small to big in sequence to obtain corresponding extracts respectively, performing decompression concentration on the extracts respectively, and collecting dry extract on chloroform part; (3) performing separation and purification on the obtained dry extract on the chloroform part by using column chromatography to obtain the hedyotis caudatifolia anthraquinone compound. The anthraquinone compound is a compound which is discovered for the first time, the types of existing compounds are enriched, the compound has good pharmacological physiological activity, has anti-tumor, hemostasis, antibacterial, purgation and diuretic effects, and is extremely suitable in the medicine absorption aspect, and the development and the utilization of the hedyotis caudatifolia are further promoted.

Description

technical field [0001] The invention belongs to the field of preparation of pharmaceutical compounds, and in particular relates to anthraquinone compound of genus saponifera and a preparation method thereof. Background technique [0002] Sword-leaf eargrass (Hedyotis caudatifolia Merr.et Metcalf), is the whole herb of Rubiaceae eargrass plant Hedyotis caudatifolia Merr.et Metcalf, also known as juvenile red, long-tailed ear grass, millennium tea, postpartum tea, tuberculosis grass, is a Guangxi Folk herbal medicine has the functions of relieving cough and reducing phlegm, invigorating the spleen and eliminating accumulation, etc. [0003] Currently, the researches involved in sword-leaf eargrass mainly include research on the microstructure of roots, stems and leaves, GC-MS analysis of volatile oil components and the protective effect of its extracts on the liver. Folks often have old Chinese medicine for the treatment of hepatitis B, and the effect is remarkable. Compared...

AI Technical Summary

Problems solved by technology

Compared with its widespread use in the folk, there are very few researches on the genus genus at home and abroad at present. The research on the chemical components of genus is almost blank except for the volatile oil components, especially there are many gaps in the research on its active ingredients. This status quo has greatly affected the rational promotion and use of P. saponifera. Therefore, it is extremely important to carry out systematic research on the active ingredients of P. raptoria. It can not only provide a material basis for clarifying the mechanism of action of P. Rational development and utilization of Auricularia fragrans resources, at the same time, provides a material basis for promoting the standardization and internationalization of Aurantium aurantium as a traditional Chinese medicine, and is of great significance for improving the relevant theories of Auricularia aeruginosa and promoting the modernization of traditional Chinese medicine

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