Hedyotis caudatifolia anthraquinone compound and preparation method thereof

A technology of sagebrush and compound, which is applied in the field of preparation of pharmaceutical compounds, can solve problems affecting the rational promotion and use of sagebrush, and achieve the effects of good pharmacological and physiological activity, suitable polarity, and promotion of development and utilization.

Active Publication Date: 2015-07-29
GUANGXI UNIV OF CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with its widespread use in the folk, there are very few researches on the genus genus at home and abroad at present. The research on the chemical components of genus is almost blank except for the volatile oil components, especially there are many gaps in the research on its active ingredients. This status quo has greatly affected the rational promotion and use of P. saponifera. Therefore, it is extremely important to carry out systematic research on the active ingredients of P. raptoria. It can not only provide a material basis for clarifying the mechanism of action of P. Rational development and utilization of Auricularia fragrans resources, at the same time, provides a material basis for promoting the standardization and internationalization of Aurantium aurantium as a traditional Chinese medicine, and is of great significance for improving the relevant theories of Auricularia aeruginosa and promoting the modernization of traditional Chinese medicine

Method used

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  • Hedyotis caudatifolia anthraquinone compound and preparation method thereof
  • Hedyotis caudatifolia anthraquinone compound and preparation method thereof
  • Hedyotis caudatifolia anthraquinone compound and preparation method thereof

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Embodiment 1

[0034] (1) The samples of Aurantium saponifera used were collected in Jinxiu Yao Autonomous County, Guangxi. Get 30kg of saponifera samples, pulverize them respectively with ethanol and water with volume concentrations of 95%, 80%, 60%, and 40% as solvents to extract saphophyllium by percolation, saphophylla and each solvent The mass ratios of both are 1:8, the combined extracts are concentrated under reduced pressure, the solvent is recovered until there is no alcohol smell, and the total extract is obtained.

[0035] (2) Add water and suspend the total extract to a concentration of 0.02-1g / ml, then sequentially extract with petroleum ether, chloroform, ethyl acetate, and n-butanol at 60-90°C, concentrate and recover the solvent under reduced pressure, respectively, and obtain petroleum Ether part dry extract, chloroform part dry extract, ethyl acetate part dry extract and n-butanol part dry extract.

[0036] (3) Use 100-200 mesh silica gel to separate the dry extract from t...

Embodiment 2

[0039] (1) Pulverize the whole herb of C. saponifera and place it in a solvent for extraction. The weight of the solvent is 4 to 12 times of the weight of C. fragrans, and the solvent is methanol; Alcoholic taste, to obtain the extract, take a small amount of extract and dry it completely to obtain the dry paste of the extract, and weigh it, and calculate the net weight of the total extract according to the quality of the obtained dry paste of the extract;

[0040] (2) Dilute the extract obtained in step (1) with water to a concentration of 0.02 to 1 g / ml according to the actual net weight, and then use the solvent petroleum ether, chloroform, ethyl acetate, and n-butanol in order from small to large polarity The corresponding extracts were obtained by extraction, respectively, the extracts were concentrated under reduced pressure, and the dry extracts were collected from the chloroform parts;

[0041] (3) Separating and purifying the dry extract from the chloroform part obtai...

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Abstract

The invention discloses a hedyotis caudatifolia anthraquinone compound and a preparation method thereof. The structural formula of the compound is shown in the specification. The preparation method of the compound comprises the following steps: (1) lixiviating hedyotis caudatifolia in a solvent, performing decompression concentration on the extract, and recovering the solvent until no alcohol taste exists; (2) adding water into the extract to dilute, then extracting with solvents petroleum ether, chloroform, ethyl acetate and n-butyl alcohol with polarities from small to big in sequence to obtain corresponding extracts respectively, performing decompression concentration on the extracts respectively, and collecting dry extract on chloroform part; (3) performing separation and purification on the obtained dry extract on the chloroform part by using column chromatography to obtain the hedyotis caudatifolia anthraquinone compound. The anthraquinone compound is a compound which is discovered for the first time, the types of existing compounds are enriched, the compound has good pharmacological physiological activity, has anti-tumor, hemostasis, antibacterial, purgation and diuretic effects, and is extremely suitable in the medicine absorption aspect, and the development and the utilization of the hedyotis caudatifolia are further promoted.

Description

technical field [0001] The invention belongs to the field of preparation of pharmaceutical compounds, and in particular relates to anthraquinone compound of genus saponifera and a preparation method thereof. Background technique [0002] Sword-leaf eargrass (Hedyotis caudatifolia Merr.et Metcalf), is the whole herb of Rubiaceae eargrass plant Hedyotis caudatifolia Merr.et Metcalf, also known as juvenile red, long-tailed ear grass, millennium tea, postpartum tea, tuberculosis grass, is a Guangxi Folk herbal medicine has the functions of relieving cough and reducing phlegm, invigorating the spleen and eliminating accumulation, etc. [0003] Currently, the researches involved in sword-leaf eargrass mainly include research on the microstructure of roots, stems and leaves, GC-MS analysis of volatile oil components and the protective effect of its extracts on the liver. Folks often have old Chinese medicine for the treatment of hepatitis B, and the effect is remarkable. Compared...

Claims

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Application Information

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IPC IPC(8): C07C50/34C07C46/10
CPCC07C46/10C07C50/34
Inventor 潘为高罗彭苏加乐庞宇舟
Owner GUANGXI UNIV OF CHINESE MEDICINE
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