Disposable premoistened wipe containing an antimicrobial protease inhibitor

A protease inhibitor, wipes technology, applied in medical preparations containing active ingredients, organic active ingredients, preparations for skin care, etc., can solve the problem of not identifying the exact composition of urine and feces that determine diaper dermatitis

Inactive Publication Date: 2001-12-05
THE PROCTER & GAMBLE COMPANY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The exact composition of urine and feces that determine diaper dermatitis has not been identified to date

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0125] Referring to Table I, the inhibitory activity of hexamidine diisethionate (recorded as IC 50 ).

[0126] Referring to Table I, column 1, the inhibitory activity of hexamidine diisethionate on fecal trypsin was assessed according to Method 2a above (ie, the method for assessing the efficacy of protease inhibitors in fecal trypsin).

[0127] Referring to Table I, column 2, the inhibitory activity of hexamidine diisethionate on purified trypsin was assessed according to Method 1a above (ie, Method for Evaluating Protease Inhibitor Efficacy in Purified Trypsin).

[0128] Referring to Table I, column 3, the effect of the hexamidine diisethionate-containing liquid composition on Inhibitory activity of purified trypsin.

[0129] fecal trypsin

IC 50 (μM)

Purified trypsin

IC 50 (μM)

Purified trypsin

(containing hexamidine diisethionate

Inhibitory activity of liquid compositions)

IC 50 (μM)

2.3

...

Embodiment 3

[0134] Referring to Table III, the antibacterial inhibitory activity of the liquid composition not containing the antimicrobial protease inhibitor was compared with that of the liquid composition containing the antimicrobial protease inhibitor. The antimicrobial protease inhibitor chosen for this evaluation was hexamidine diisethionate.

[0135] The antimicrobial inhibitory activity of hexamidine isethionate is reported as the minimum inhibitory concentration ("MIC") of hexamidine isethionate required to inhibit a particular organism. Table III, column 1 shows the specific microorganisms against which the antimicrobial inhibitory activity of the hexamidine bisethionate was evaluated. Referring to Table III, column 2, the ATCC strain identification numbers of the microorganisms listed in column 1 are shown.

[0136] Referring to Table III, column 3, the antimicrobial inhibitory activity of liquid compositions without antimicrobial protease inhibitors is shown. Liquid composit...

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Abstract

A disposable wipe which comprises a substrate, an antimicrobial protease inhibitor, and a liquid. The antimicrobial protease inhibitor may be added directly to the substrate and / or added directly to the liquid. The antimicrobial protease inhibitor is capable of inhibiting deleterious fecal microorganisms and protease enzymes thereby aiding in the prevention of diaper dermatitis. The wipe may optionally include other ingredients examples of which include humectants, emollients, surfactants, fragrances, emulsifiers, and preservatives. Also disclosed is a skin care regimen using the disposable wipe of the current invention in conjunction with a disposable absorbent article. For wearers of disposable absorbent articles, skin health in the area of the skin contacted by the disposable absorbent article is prophetically maintained and / or improved by utilizing the disposable wipe of the present invention in conjunction with the disposable absorbent article.

Description

field of invention [0001] The present invention relates to disposable premoistened wipes, and more particularly, the present invention relates to disposable premoistened wipes comprising antimicrobial protease inhibitors effective against harmful fecal microorganisms and proteases. Background of the invention [0002] Pre-moistened wipes are well known in the art. Such wipes are also known as "wet wipes", "baby wipes" and "towelettes". Pre-moistened wipes comprise a nonwoven fibrous substrate that is wetted with a liquid prior to use. The substrate may comprise various combinations of cellulosic fibers, synthetic polymer fibers such as polyester, polypropylene, polyethylene, and the like. The substrate may also include a binder to hold the fibers together. The substrate is usually wetted with a liquid such as water. Liquids may include various other ingredients such as wetting or wetting agents, emollients, surfactants, emulsifiers, pH adjusters, fragrances, powders, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A47K7/00A01N25/34A01N37/52A01N39/00A41B17/00A61K8/02A61K8/40A61K9/70A61K31/155A61K45/00A61L2/18A61Q17/00A61Q19/00
CPCA01N25/34A61Q17/005A61Q19/00Y10T442/2525A61K8/0208A01N39/00A61K8/40A61K2800/782A01N37/52A61P17/00A01N2300/00A61K31/135
Inventor 弗朗西斯·J·鲁尔克马克·F·理查兹斯科特·E·奥斯本
Owner THE PROCTER & GAMBLE COMPANY
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