Ditropan hydrochloride dripping pills and the prepn process

A technology of oxybutynin hydrochloride and hydrochloric acid, which is applied in the field of oxybutynin hydrochloride dripping pills and its preparation, can solve the problems of affecting the therapeutic effect of oxybutynin hydrochloride, low dissolution rate and dissolution rate, and large proportion of excipients , to achieve the effect of convenient carrying and taking, improved dissolution rate and dissolution rate, and reduced dosage of excipients

Inactive Publication Date: 2004-09-08
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Oxybutynin Hydrochloride (Oxybutynin Hydrochloride) is an anticholinergic drug. It is odorless and dissolves in water. Its tablet disintegrates long, has low dissolution rate and dissolution rate, poor absorption, low bioavailability, and a large proportion of excipients. Children and the elderly , Bedridden patients and patients with dysphagia are inconvenient to take and have poor compliance, which affects the therapeutic effect of oxybutynin hydrochloride

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0049] prescription:

[0050] Oxybutynin Hydrochloride 5g

[0051] Macrogol 6000 15g

[0052] Makes 1000 capsules

[0053] Preparation method: Take the fine powder of oxybutynin hydrochloride that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 6000 matrix, stir well, use simethicone oil as the coolant, make pellets by drop method, dry, Instantly.

example 2

[0055] prescription:

[0056] Oxybutynin Hydrochloride 5g

[0057] Macrogol 4000 15g

[0058] Makes 1000 capsules

[0059] Preparation method: Take the fine powder of oxybutynin hydrochloride that has been superfinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 matrix, stir well, use simethicone as a coolant, make pellets by drop method, dry, Instantly.

example 3

[0061] prescription:

[0062] Oxybutynin Hydrochloride 5g

[0063] Macrogol 6000 5g

[0064] Macrogol 4000 10g

[0065] Makes 1000 capsules

[0066] Preparation method: Take the fine powder of oxybutynin hydrochloride that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten mixed matrix of polyethylene glycol 4000 and polyethylene glycol 6000, stir well, use simethicone oil as the coolant, Drop system into legal pills, dry, and get it.

[0067] 4. Example 4

[0068] prescription:

[0069] Oxybutynin Hydrochloride 5g

[0070] Glyceryl monostearate 15g

[0071] Makes 1000 capsules

[0072]Preparation method: Take the oxybutynin hydrochloride fine powder that has been superfinely pulverized and passed through 200 sieves, add it to the molten glyceryl monostearate base, mix well, use ice water as the coolant, make pellets by drop method, and dry to obtain .

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PUM

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Abstract

The present invention is Ditropan hydrochloride dripping pill prepared through superfine crushing and dripping pill producing process. The Ditropan hydrochloride dripping pill has raised disintegrating and dissolving speed, high digestion rate and digestion degree, fast acting, high stability, reduced supplementary material consumption, low production cost and easy carrying about and taking. It may be haven in mouth or swallowed, has excellent conformity and is especially suitable for children, the aged and other patients with dysphagia.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to oxybutynin hydrochloride dropping pills and a preparation method thereof. Background technique [0002] Oxybutynin Hydrochloride (Oxybutynin Hydrochloride) is an anticholinergic drug. It is odorless and dissolves in water. Its tablet disintegrates long, has low dissolution rate and dissolution rate, poor absorption, low bioavailability, and a large proportion of excipients. Children and the elderly 1. Bedridden patients and patients with dysphagia are inconvenient to take and have poor compliance, which affects the therapeutic effect of oxybutynin hydrochloride. [0003] The present invention is to make the oxybutynin hydrochloride drop pills by applying the ultrafine pulverization technology and the drop pill preparation technology, thereby overcoming the above defects of the oxybutynin hydrochloride tablets, so that the therapeutic effect of the o...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K9/20A61K31/221A61P25/00A61P43/00
Inventor钱进许军彭红李平朱丹刘孝乐
OwnerHONGYI SCI & TECH CO LTD NANCHANG