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Extractive and its application in medicine

A technology for extracts and medicines, applied in the field of extracts and their medicinal uses

Active Publication Date: 2005-08-31
INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, no report on the antidepressant effect of the extract of the above four components and containing 50-90% by weight of total flavonoids

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Preparation of total flavonoids extracts from a mixture of inula inulae, ochre, bamboo leaves and tempeh

[0023] Preparation

[0024] Add 70% ethanol to reflux extraction 3 times (V / W=6:1), filter, concentrate under reduced pressure, and freeze-dry to obtain 784g of extract. Disperse with water to form a suspension solution (the weight ratio of the extract to water is 1:1.5), extract 4 times with petroleum ether (the volume ratio of petroleum ether to the suspension solution is 1:1), discard the petroleum ether layer, and further extract the water layer with water. Disperse (medicinal material: water (1:1)), centrifuge, and discard the precipitate; the water layer is washed with AB-8 macroporous resin (the sample volume of each 4L resin is equivalent to 3kg medicinal material) with water for two column volumes, discarded and washed with water Dehydration, elution with 70% ethanol until the eluate was light yellow, 70% ethanol eluate was concentrated and dried under re...

Embodiment 2

[0026] Evaluation of the antidepressant effect of the extract of Example 1

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PUM

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Abstract

An extract for preventing and treating depression is extracted from 4 Chinese-medicinal materials including inula flower, hematite, bamboo leaf, etc.

Description

field of invention [0001] The present invention relates to the extract obtained from inula inulae, dah stone, bamboo leaves and tempeh, which contains 50-90% by weight of total flavonoids, and its use in antidepressant. Background technique [0002] The extract of the present invention is obtained from inula inula, ocher, bamboo leaves and fermented soya bean, and the components contained inula inula, ocher ocher, bamboo leaf and fermented soya bean are non-toxic traditional Chinese medicinal materials collected in Pharmacopoeia. So far, there is no report on the antidepressant effect of the extract of the above four components and containing 50-90% by weight of total flavonoids. Contents of the invention [0003] The present inventors have now found that an extract consisting of Inula inula, ochre, bamboo leaves and tempeh containing 50-90% by weight of total flavonoids has an unexpected antidepressant effect, and the present invention has been completed based on the abov...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/78A61K31/352A61K31/7048A61P25/24
Inventor 李云峰张有志于能江袁莉赵毅民肖文彬罗质璞
Owner INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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