Check patentability & draft patents in minutes with Patsnap Eureka AI!

General saponin extract of Anemone flaccida Fr. Schmidt

A technology of total saponins and extracts, which is applied in the field of total saponins of Diwu saponins, can solve the problems of inability to achieve industrialized production and development of new medicines, low purity, and many impurities of total saponins of Diwu saponins, and achieve low cost, high purity, The effect of less impurities

Inactive Publication Date: 2006-10-11
广州康和药业有限公司
View PDF0 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing preparation methods are water extraction, alcohol extraction, and water extraction and alcohol precipitation methods. The total saponins of Diwu saponins obtained by these methods have many impurities and low purity, which cannot meet the requirements of industrial production and new drug development.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Take 1.5kg of Radix Rhizoma Radix, add 9kg of water, decoct for 2 hours, filter, repeat the operation three times, combine the filtrate, concentrate into an extract, and measure the extract with a relative density of 1.07 (60°C) at 60°C with a hydrometer , let cool to room temperature, add 95% ethanol to make the alcohol content 60%, shake well, let it stand for 12 hours, filter, recover ethanol until there is no alcohol smell, put the filtrate on a D101 macroporous resin column, wash with water until The effluent was colorless, and the water was discarded; then eluted with 8kg of 70% ethanol at a flow rate of 9ml / min, collected the eluate, recovered the ethanol until it had no alcohol smell, concentrated it into a thick paste, put it in a vacuum dryer, and heated it at 760mmHg, Vacuum drying at 80° C. for 12 hours gave massive crystals, which were pulverized and sieved to obtain 99.9 g of powder with a purity of 88%.

[0019] The method for measuring the purity of the ...

Embodiment 2

[0035] Take 1.5kg of Radix Rhizoma Radix, add 12kg of water, decoct for 1 hour, filter, repeat the operation twice, combine the filtrate, concentrate it into an extract, measure the extract with a relative density of 1.04 at 40°C with a hydrometer, and let it cool , add 95% ethanol to make the alcohol content to 50%, shake well, let it stand for 8 hours, filter, recover the ethanol until there is no alcohol smell, put the filtrate on a D101 macroporous resin column, wash with water until the effluent is colorless, Discard the water; then elute with 6kg of 50% ethanol at a flow rate of 8ml / min, collect the eluent, recover the ethanol until it has no alcohol smell, concentrate it into a thick paste, put it in a vacuum dryer, and dry it under vacuum at 700mmHg and 60°C for 8 hours, blocky crystals were obtained, pulverized and sieved to obtain 100.2 g of powder with a purity of 86%.

Embodiment 3

[0037] Take 1.5kg of Radix Rhizoma Radix, add 15kg of water, decoct for 3 hours, filter, repeat the operation four times, combine the filtrates, concentrate into an extract, measure the extract with a relative density of 1.10 at 70°C with a hydrometer, and let it cool , add 95% ethanol to make the alcohol content to 70%, shake well, let it stand for 16 hours, filter, recover the ethanol until there is no alcohol smell, put the filtrate on a D101 type macroporous resin column, wash with water until the effluent is colorless, Discard the water; then elute with 10.5kg60% ethanol at a flow rate of 8ml / min, collect the eluent, recover the ethanol until it has no alcohol smell, concentrate it into a thick paste, put it in a vacuum dryer, and dry it under vacuum at 560mmHg and 100°C After 13 hours, massive crystals were obtained, which were pulverized and sieved to obtain 99.7 g of powder with a purity of 85%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
densityaaaaaaaaaa
Login to View More

Abstract

The invention discloses an extract of Anemone flaccida Fr. Schmidt saponins, which is prepared from the following steps: (1) screening rhizome of Anemone flaccida Fr. Schmidt, disintegrating, sieving, (2) charging 6-10 by weight times of water into Anemone flaccida Fr. Schmidt powder, boiling, filtrating, merging the filter liquor, (3) concentrating the filtrate into concrete, (4) charging 95% of ethanol into the concrete, stewing -16-4 hours, filtrating, reclaiming ethanol till no alcohol smell is present, (5) passing the filter liquor through macroscopic adsorption resin column, water scrubbing, eluting with 50-70% of ethanol, collecting the eluent, (6) reclaiming ethanol till no alcohol smell is present, concentrating, drying, disintegrating and sieving.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract, in particular to a total saponin extract of Diwu root extracted and refined from the rhizome of the traditional Chinese medicine Diwu (Anemone flaccida Fr. Schmidt). technical background [0002] Arthritis and rheumatoid arthritis are common and frequently-occurring diseases, especially rheumatoid arthritis, which is an autoimmune disease. Its pathogenesis is quite complicated, it involves a wide range of areas, and it is quite stubborn. There are records about bone and joint diseases, which are called Arthralgia Syndrome. Doctor trained in Western medicine thinks that rheumatism is a large class of diseases that various reasons cause with pain in bones, joints, muscles and their accessory tissues as the main manifestation. Currently, the American Academy of Rheumatology (ARA) divides rheumatism into 10 categories, which have been adopted by the World Health Organization. These diseases...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61K31/704A61P19/02C07J63/00
Inventor 黄漫翔
Owner 广州康和药业有限公司
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com