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Ubiquitin-specific protease

A specific, protease-based technology, applied in the field of ubiquitin-specific proteases, can solve the problems of truncated member division, difficulties, etc.

Inactive Publication Date: 2006-10-11
NOVARTIS AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of these new sequences represent truncated members and thus true classification of these proteins as members of the deubiquitin family has been difficult

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0898] The gene expression profile of USP_N01 corresponding to SEQ ID.No.1 and SEQ ID.No.2 is in figure 1 display.

Embodiment 2

[0900] The gene expression profile of USP_N07 corresponding to SEQ ID.No.5 and SEQ ID.No.6 is in figure 2 display.

Embodiment 3

[0902] The gene expression profile of USP_N11 corresponding to SEQ ID.No.9 and SEQ ID.No.10 is in image 3 display.

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Abstract

The present invention provides novel members of the family of deubiquitinating enzymes (DUBs) as well as biologically, diagnostically or therapeutically useful fragments, derivatives, and homologues thereof, which are useful in research, biological, clinical, therapeutic as well as prognostic and diagnostic purposes. Furthermore, the polynucleotides and polypeptides provided by the present invention are useful for the treatment and diagnosis of breast cancer, leukemia or brain disorders.

Description

Invention field [0001] The present invention relates to a ubiquitin-specific protease (USP), in particular to a new member of the desubiquitin protease (DUB) family. Background of the invention [0002] Ubiquitin is a protein of 76 amino acid residues that is found in all eukaryotic cells and whose sequence is extremely conserved from protozoa to vertebrates. This protein plays an important role in a variety of cellular processes such as ATP-dependent selective degradation of cellular proteins, maintenance of chromatin structure, regulation of gene expression, stress response, and ribosome biogenesis. Conjugation to the small eukaryotic protein, ubiquitin, can functionally modify or target the protein for degradation by the proteasome. Similar to protein phosphorylation, protein ubiquitination is dynamic, involving an enzyme that adds ubiquitin (ubiquitin conjugase) and an enzyme that removes ubiquitin. The removal of ubiquitin modification or deubiquitin action is performed by t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/12C12N9/64
CPCC12N9/6421A61P35/00A61P35/02
Inventor A·布林格尔R·L·蔡S·克西达B·皮埃拉N·R·尼尔马拉
Owner NOVARTIS AG
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