Apparatus for producing tissue arrays

A tissue array and tissue technology, which is applied in the direction of measuring devices, test sample preparation, sampling, etc., can solve the problems of expensive devices and inability to solve positioning, and achieve the effect of precise positioning

Inactive Publication Date: 2007-03-07
LEICA MICROSYST NUSSLOCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0011] This device is very expensive and additionally does not solve th

Method used

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  • Apparatus for producing tissue arrays
  • Apparatus for producing tissue arrays

Examples

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Embodiment Construction

[0026] FIG. 1 is a view of a device for producing a tissue array with a receiver block 1 and a donor block 2 with tissue 3 to be examined. The donor block 2 and the receiving block 1 are arranged on a turntable 13 . In addition, a pivotable needle holder 14 is provided, which carries the first hollow needle 4 and the second hollow needle 5 . The first hollow needle 4 is used to create a punch in the receiving block 1 , while the second hollow needle 5 is used to extract a tissue core from the tissue 3 .

[0027] The device has a boom arrangement supported by an axis of rotation 16, which has two interconnected scissor arms 7 and 8, wherein the end of the first scissor arm 7 has a rest for a plunger 15 Frame 9, the plunger is used to selectively manipulate the first and second hollow needles 4,5. The end of the second scissors arm 8 is provided with a positioning pin 10, and a positioning array 11 with a single positioning hole 12 is assigned to the positioning pin.

[0028]...

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Abstract

An apparatus for producing a tissue array, having at least one receiver block ( 1 ) and at least one donor block ( 2 ) that comprises tissue ( 3 ) to be investigated, is described. The donor block ( 2 ) comprises tissue ( 3 ) to be investigated, a first hollow needle ( 4 ) for creating a cavity in the receiver block ( 1 ), and a second hollow needle ( 5 ) for removing a sample from the tissue ( 3 ) and introducing the sample ( 3 ) into the cavity of the receiver block ( 1 ), being provided. For positioning of the first and/or the second hollow needle ( 4; 5 ) above the receiver block ( 1 ) and/or the donor block ( 2 ), a positioning array ( 11 ) having predefined markings, as well as a movably mounted lever, are provided for transferring the position of the markings onto a corresponding position on the donor block ( 2 ) and/or onto a corresponding position on the receiver block ( 1 ).

Description

technical field [0001] The invention relates to a device for producing tissue arrays according to the preamble of claim 1 . Background technique [0002] Tissue arrays, ie tissue microarrays (TMA), contain a plurality of different tissue samples in a single receiving block or paraffin block. The receiver block is typically sectioned with the aid of a microtome, and the sections are mounted on slides. The slide contains a number of different tissue samples. With a large number of tissue samples on a single slide, all samples can be stained or processed under the same conditions. Consequently, very complex and expensive staining methods such as immunohistochemistry (IHC) or in situ hybridization (IHC) are also effectively used to visualize DNA or RNA. [0003] However, the production of tissue arrays is very time-consuming, since a large number of different samples (up to 1000) are arranged next to each other in a receiving block. Tissue cores are punched out from differen...

Claims

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Application Information

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IPC IPC(8): G01N1/28G01N33/48
CPCG01N1/36G01N2001/368
Inventor R·瓦尔特R·梅茨纳
Owner LEICA MICROSYST NUSSLOCH
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