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Medicine for treating infantile asthma and its prepn. method

A technology of children's asthma and medicine, applied in the field of medicine for treating acute attack of children's bronchial asthma and its preparation

Inactive Publication Date: 2007-04-18
北京羚锐伟业科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] To sum up, most of the traditional Chinese medicines currently on the market for treating asthma are Fuzheng Gubeng drugs in the asthma remission period, while the patent medicines suitable for children with bronchial asthma attacks are basically medicines for treating heat asthma syndrome, and are clearly suitable for children with bronchial asthma. The main medicine for children with bronchial asthma cold asthma syndrome is still rare

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Embodiment 1, the preparation of the present invention's medicine for treating asthma in children

[0048] Drugs for treating asthma in children, the prescription of which is as follows: 150g of ephedra, 100g of Zanthoxylum bungeanum, 110g of short ground tea, 86g of perilla seed, 86g of coltsfoot flower, 86g of bitter almond, 65g of cicada slough, 86g of Pinellia chinensis, 65g of tangerine peel, mulberry Skin 86g and licorice 46g.

[0049] The method for preparing the medicine for treating asthma in children comprises the following specific steps:

[0050] 1) Weigh the medicinal materials according to the components and their weights in the above-mentioned traditional Chinese medicine prescription, and perform routine pretreatment;

[0051] 2) mix Zanthoxylum, coltsfoot, perilla seeds (crushed) and tangerine peel, then put it into water 6 times the total weight of Zanthoxylum, coltsfoot, perilla and tangerine peel, and distill for 5 hours to obtain About 1.24ml of v...

Embodiment 2

[0062] Embodiment 2, the experiment of the influence of the medicine of the present invention for treating infantile asthma on protein asthma model guinea pigs

[0063] Adopt the medicine for the treatment of infantile asthma prepared in Example 1 (named as Chuanxiu Kang Oral Liquid for clinical experiments), carry out animal experiments on protein asthma model guinea pigs, and investigate the asthmatic effect of the medicine of the present invention on protein asthma model guinea pigs by control experiment. The specific experimental process is as follows:

[0064] (1) Take 70 juvenile guinea pigs weighing about 240.9±29.8g, half male and half male, and randomly divide them into 7 groups, namely ① model blank group, ② asthma model group, ③ Briconyl group, ④ Xiaoqinglong mixture ⑤~⑦Huchuankang Oral Liquid low-, medium-, and high-dose groups, see Table 1 for specific groupings.

[0065] group

number of animals

(Only)

dosage

(g / kg)

Breathing ...

Embodiment 3

[0081] Embodiment 3, the experiment of the influence of the medicine of the present invention for the treatment of infantile asthma on guinea pigs model of histamine phosphate asthma

[0082] The medicine for the treatment of children's asthma that adopts embodiment 1 preparation (clinical experiment named as Chuanxiu Kang oral liquid), carries out animal experiment to histamine phosphate asthma model guinea pig, by contrast experiment, investigates the medicine of the present invention to the effect of histamine phosphate asthma model guinea pig Asthma effect. The specific experimental process is as follows:

[0083] (1) Take several juvenile guinea pigs with a body weight of 204.1±16.8g, put them into a spray box, spray histamine phosphate at a concentration of 0.1% mg / ml for 10 seconds with ultrasonic atomization, observe the asthmatic response of the guinea pigs, and select qualified ones 60 rats (asthma incubation period no more than 150s are qualified), male or female, ...

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Abstract

A Chinese medicine for treating the acute bronchial asthma of baby is prepared from 11 Chinese-medicinal materials including ephedra, perilla seed, tangerine peel, mulberry bark, etc. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, in particular to a medicine for treating acute attack of children's bronchial asthma and a preparation method thereof. Background technique [0002] Asthma is a common respiratory allergic disease in childhood. The disease occurs all over the world, the global prevalence rate is 0.3-9.2%, and the prevalence rate in my country is 2%. Therefore, the research on the pathogenesis and prevention of the disease is highly valued at home and abroad. Children's bronchial asthma belongs to the category of "asthma syndrome (disease)" in traditional Chinese medicine. The acute attack stage witnesses mainly two types: cold wheezing and hot wheezing. Its cold asthma syndrome is mostly caused by damp phlegm lying in the lung diaphragm, inadvertent daily life, exogenous wind-cold, pathogenic factors in the lungs, triggering phlegm and drinking, abnormal circulation of lung qi, dyspnea due to adverse...

Claims

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Application Information

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IPC IPC(8): A61K36/758A61K36/8888A61K9/08A61K9/10A61P11/06A61K35/64
Inventor 张军兵蔡光先汪平余家相武惠斌
Owner 北京羚锐伟业科技有限公司
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