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Composition comprising fermented tea extract as the main component and having effect of increasing adiponectin

A composition and extract technology, which is applied in the direction of medical preparations containing active ingredients, drug combinations, and the functions of food ingredients, to achieve the effect of expanding the size of LDL particles and high safety

Inactive Publication Date: 2007-06-06
SUNTORY HLDG LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, until now, there is no safe diet or composition that increases the concentration of adiponectin in the blood or expands the size of LDL particles to reduce the concentration of small and dense LDL in the blood.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Embodiment 1 The manufacture of fermented tea extract

[0063] Add 1000 ml of deionized water to 60 g of semi-fermented oolong tea leaves, and extract at 95° C. for 10 minutes. This was filtered, and the obtained filtrate was subjected to centrifugation. The obtained supernatant was heat-sterilized (95 degreeC, 6 second), and freeze-dried to obtain 15 g of fermented tea extracts. The analysis results of the main components in the total fermented tea extract are shown in Table 1.

[0064] [Table 1] Contents of main components of oolong tea extract

[0065] Ingredient content (mg)

[0066] Gallic acid 52.5

[0067] Epigallocatechin 507

[0068] Catechin 27.2

[0069] Caffeine 551

[0070]Epicatechin 151

[0071] Epigallocatechin gallate

[0072] 454

[0073] (Epigallocatechin Gallate)

[0074] gallocatechin gallate

[0075] 38.1

[0076] (Gallocatechin Gallate)

[0077]...

Embodiment 2

[0080] Example 2 The effect of increasing blood adiponectin produced by drinking oolong tea extract

[0081] After fully informed consent to the subjects, those who voluntarily participate in the experiment are the subjects. The previous diseases of the subjects were 12 old myocardial infarction, 10 stable angina pectoris, average age 64.3±7.2 years, BMI 23±4, 17 males and 5 females. In addition, the risk factors for coronary artery disease in the 22 subjects were 7 hypertension, 9 diabetes, 12 hypercholesterolemia, 7 obesity, and 5 smoking. Simultaneously carry out the test.

[0082] As a fermented tea extract, after dissolving 1.5 g of the oolong tea extract obtained in Example 1 in 1000 ml of deionized water, drink the resulting solution in 1000 ml a day before going to bed in divided doses, and after drinking for one month, Measure blood adiponectin, total cholesterol, LDL cholesterol, HDL cholesterol, neutral fat, LDL particle size, and compare with the value before dri...

Embodiment 3

[0090] Embodiment 3 powder and granule

[0091] 53 g of lactose and 16 g of cornstarch were mixed with 10 g of the oolong tea extract obtained in Example 1, and the mixture was wet-granulated with a cornstarch binder to prepare powders and granules.

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PUM

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Abstract

It is intended to provide a composition which originates in a natural material, has a high safety without showing any side effects when continuously taken over a long time, is highly usable as a health drink, elevates the blood adiponectin concentration, enlarges LDL particles, and lowers small dense LDL concentration to thereby prevent diabetes and heart diseases such as coronary artery disease or ameliorate symptoms of these diseases. A composition containing a fermented tea extract as the active ingredient and having effects of increasing adiponectin and enlarging LDL particles.

Description

technical field [0001] The present invention relates to a composition for preventing heart diseases such as diabetes and coronary artery disease or improving the symptoms of these diseases, which uses fermented tea extract as an active ingredient, which has the effect of increasing adiponectin in the body, especially blood, and expanding the particle size of LDL. Background technique [0002] At present, as the main cause of death of the Japanese population, the deaths caused by heart disease and cerebrovascular disease account for about one-third, which is increasing year by year. In order to avoid the occurrence of the above-mentioned ischemic diseases, it is very important to change daily habits such as smoking and lack of exercise, and to prevent risk factors such as hypertension, hyperlipidemia, diabetes and other diseases. On the other hand, for patients with old myocardial infarction and stable angina pectoris who already suffer from coronary artery disease, secondary...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/82A61P3/04A61P3/10A23L1/30
CPCA61K36/82A23V2002/00A23L1/3002A23L33/105A61P3/04A61P3/06A61P3/10A61P9/00A23V2250/214A23V2200/3262
Inventor 岛田健永吉川纯一
Owner SUNTORY HLDG LTD
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