Method for treating or preventing Alzheimer's disease
a technology for alzheimer's and a method of treatment and prevention, applied in the field of medicinal chemistry, can solve problems such as mental confusion and memory impairment, and achieve the effect of increasing the insulin sensitivity of the patient and improving the mentation of the patien
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Insulin Stimulates the Expression of AD7c-NTP, a Protein which causes Neurons to Exhibit Neuronal Sprouting and Apoptosis
[0038] Insulin is an important mediator of growth and differentiation in CNS neurons. Insulin stimulated differentiation of PNET2 cells was associated with rapid (within 10 minutes) but transient increases in the levels of the 39 kD, 18 kD and 15 kD NTP species, followed by sustained increases in synthesis and steady state levels of all five NTP species. In contrast, the failure of insulin to induce differentiation of PNE-T1 cells was associated with absent insulin modulation of NTP.
[0039] Analysis of the signal transduction pathways demonstrated that the insulin-induced up-regulation of NTP molecules in PNET2 cells was mediated through phosphorylation of the insulin receptor substrate-1 (IRS-1) and the insulin receptor β subunit (IRβs) itself. In PNET1 cells, the lack of insulin responsiveness was associated with impaired insulin-mediated tyrosyl phosphorylatio...
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