Methods and materials for treating nerve injuries and neurological disorders

a nerve injury and neurological disorder technology, applied in the field of methods and materials for treating nerve injuries and/or neurological disorders, can solve the problems of muscle damage, nerve damage, nerve damage, etc., and achieve the effect of improving the healing effect, and improving the healing

Pending Publication Date: 2021-08-12
PETRUCCI GARY M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The described method and composition demonstrate potential in improving symptoms of nerve injuries and neurological disorders by facilitating nerve repair and regeneration, as evidenced by the administration of amnion tissue and stem cells, which can lead to improved neurological function and quality of life for affected mammals, including humans.

Problems solved by technology

Nerves are fragile and can be damaged by pressure, stretching, or cutting.
Injury to a nerve can stop signals to and from the brain, causing muscles not to work properly, and a loss of feeling in the injured area.
The amnion tissue preparation can lack viable cells.
The amnion tissue preparation can lack viable cells.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0010]This document provides methods and materials for treating nerve injuries (e.g., spinal cord injury) and / or neurological disorders (e.g., brain trauma, stroke, or dementia) using compositions that include an amnion tissue preparation (e.g., human amnion tissue preparation) and / or a stem cell preparation (e.g., a human stem cell preparation).

[0011]A nerve injury and / or neurological disorder can affect the central nervous system or the peripheral nervous system. The term “nerve injury” as used herein refers to any damage (e.g., crush, contusion, stretch, laceration, or severing) to a nervous tissue (e.g., nerve cells or neuroglia) causing an interruption in conduction of the impulse down the nerve fiber. Nerve injuries can include, without limitation, a spinal cord injury, a peripheral nerve injury, and a traumatic brain injury. The term “neurological disorder” as used herein refers to any condition that affects (e.g., directly or indirectly) the function of the nervous system. N...

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Abstract

This document provides methods and materials for treating nerve injuries and / or neurological disorders. For example, compositions including an amnion tissue preparation and / or a stem cell preparation as well as methods for using such compositions to treat a nerve injuries and / or neurological disorders are provided.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation of U.S. patent application Ser. No. 15 / 567,160, filed Oct. 17, 2017, which is a National Stage Application of PCT / US17 / 16225, filed Feb. 2, 2017, which claims the benefit of U.S. Provisional Application No. 62 / 292,009, filed Feb. 5, 2016, and U.S. Provisional Application No. 62 / 293,866, filed Feb. 11, 2016, the content of which Applications are incorporated herein by reference in their entirety.BACKGROUND1. Technical Field[0002]This document relates to methods and materials for treating nerve injuries and / or neurological disorders. For example, this document provides methods and materials for using compositions (e.g., injectable formulations) that include an amnion tissue preparation and / or a stem cell preparation to treat nerve injuries and / or neurological disorders.2. Background Information[0003]Nerves are fragile and can be damaged by pressure, stretching, or cutting. Injury to a nerve can stop signal...

Claims

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Application Information

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Patent Type & AuthorityApplications(United States)
IPC IPC(8): A61K35/50A61K35/12A61L27/36A61L27/50A61K35/28A61L27/38
CPCA61K35/50A61K35/12A61L27/3683A61L27/507A61K35/28A61L2400/06A61L27/3675A61L27/3878A61L27/3604A61L2430/40A61L2430/32A61L27/3834
InventorPETRUCCI, GARY M.
OwnerPETRUCCI GARY M