Method for preparing N-fatty acyl group amino acid compound

Abstract

The invention discloses a method for preparing an N-fatty acyl group amino acid compound. The method is characterized in that fatty acid methyl ester and amino acid sodium serve as raw materials, the one-step synthesis method is adopted under the action of a metallic oxide catalyst, an N-fatty acyl group amino acid sodium surface active agent is compounded, and the mole ratio of the raw material of fatty acid methyl ester to the raw material of amino acid sodium is 1.2-1.8 to 0.7-1. The proportion of the raw materials is appropriate; basically, no by-product is produced; the product synthetic ratio reaches up to 87 percent or more, the purity is high, the problems that in a traditional acyl chloride method, a large amount of waste acid is produced and needs to be processed, the operation technology is complex, and the raw material of PCl3 is large in irritation, and the method conforms to the green chemistry principle. The dosage of the catalyst is reasonable; by means of the catalyst, the production efficiency is greatly improved in the preparing process, the production procedure is shortened, the product quality is improved, and good products can even be directly used as raw materials of the pharmaceutical industry.

Description

technical field

[0001] The invention relates to a method for preparing N-fatty acyl amino acid compounds, belonging to the technical field of organic compound synthesis. Background technique

[0002] In recent years, with the deepening of sustainable development thinking and the enhancement of human environmental protection awareness, some corrosion inhibitors will be subject to more and more restrictions in use due to their high toxicity and poor biodegradability. Therefore, research It is an urgent problem to develop high-efficiency, low-toxicity, and environment-friendly corrosion inhibitors. Amino acid compounds have the characteristics of wide sources, non-toxicity and easy degradation, and have become an important direction for the research and development of corrosion inhibitors.

[0003] With the rapid development of science and technology, the research, production and application of surfactants continue to deepen and expand, and new surfactants are constantly comin...

Examples

Embodiment 1

[0023] The molar ratio of raw materials methyl laurate and sodium glycinate is 1.2:0.7, the mixture of potassium oxide and magnesium oxide with a molar ratio of 1:1 is used as the metal oxide catalyst, and the amount of catalyst added is 0.05 of the total amount of reactants. wt%.

[0024] One-step synthesis synthesis preparation: sodium glycinate is continuously fed from the sodium glycinate storage tank into a mixing reaction device composed of a primary and secondary mixer connected in series, and methyl laurate is continuously added into the primary and secondary mixers according to the raw material ratio of the proportioning amount. In the secondary mixer, the reaction materials are firstly heated to 20-40 degrees in the mixer, then a proportioned amount of metal oxide catalyst is added, and finally the mixing reaction is carried out, and the reaction time is 3 hours.

[0025] Among them, the reaction temperature of the primary mixer is generally controlled between 20 and...

Embodiment 2

[0028] The molar ratio of raw materials methyl laurate and sodium alanine is 1.2:0.7, and the mixture of potassium oxide and magnesium oxide with a mixing molar ratio of 1:1 is used as the metal oxide catalyst, and the amount of catalyst added is the total amount of reactants 0.08wt%.

[0029] According to the one-step synthesis method in Example 1, the reaction temperature of the primary mixer is generally controlled between 20 and 30 degrees. Specifically, the temperature of the feed port of the primary mixer is controlled at 20 degrees. The outlet temperature of the device is controlled at 25 degrees; the pH value is maintained at 10. The reaction temperature of the secondary mixer is generally controlled between 30 and 40 degrees. Specifically, the temperature of the inlet of the secondary mixer is controlled at 30 degrees, and the temperature of the outlet of the secondary mixer is controlled at 35 degrees; the pH value is maintained at 10.

[0030] After the reaction w...

Embodiment 3

[0032] The molar ratio of raw materials methyl laurate and sodium glutamate is 1.8:0.7, and the mixture of potassium oxide and magnesium oxide with a molar ratio of 2:1 is used as the metal oxide catalyst, and the amount of the catalyst added is the total amount of reactants 0.05wt%.

[0033] According to the one-step synthesis method in Example 1, the reaction temperature of the primary mixer is generally controlled between 20 and 30 degrees. Specifically, the temperature of the feed port of the primary mixer is controlled at 25 degrees. The outlet temperature of the device is controlled at 25 degrees; the pH value is maintained at 10. The reaction temperature of the secondary mixer is generally controlled between 30 and 40 degrees. Specifically, the temperature of the inlet of the secondary mixer is controlled at 35 degrees, and the temperature of the outlet of the secondary mixer is controlled at 35 degrees; the pH value is maintained at 13 .

[0034] After the reaction w...

technical field

[0001] The invention relates to a method for preparing N-fatty acyl amino acid compounds, belonging to the technical field of organic compound synthesis. Background technique

[0002] In recent years, with the deepening of sustainable development thinking and the enhancement of human environmental protection awareness, some corrosion inhibitors will be subject to more and more restrictions in use due to their high toxicity and poor biodegradability. Therefore, research It is an urgent problem to develop high-efficiency, low-toxicity, and environment-friendly corrosion inhibitors. Amino acid compounds have the characteristics of wide sources, non-toxicity and easy degradation, and have become an important direction for the research and development of corrosion inhibitors.

[0003] With the rapid development of science and technology, the research, production and application of surfactants continue to deepen and expand, and new surfactants are constantly comin...

Examples

Embodiment 1

[0023] The molar ratio of raw materials methyl laurate and sodium glycinate is 1.2:0.7, the mixture of potassium oxide and magnesium oxide with a molar ratio of 1:1 is used as the metal oxide catalyst, and the amount of catalyst added is 0.05 of the total amount of reactants. wt%.

[0024] One-step synthesis synthesis preparation: sodium glycinate is continuously fed from the sodium glycinate storage tank into a mixing reaction device composed of a primary and secondary mixer connected in series, and methyl laurate is continuously added into the primary and secondary mixers according to the raw material ratio of the proportioning amount. In the secondary mixer, the reaction materials are firstly heated to 20-40 degrees in the mixer, then a proportioned amount of metal oxide catalyst is added, and finally the mixing reaction is carried out, and the reaction time is 3 hours.

[0025] Among them, the reaction temperature of the primary mixer is generally controlled between 20 and...

Embodiment 2

[0028] The molar ratio of raw materials methyl laurate and sodium alanine is 1.2:0.7, and the mixture of potassium oxide and magnesium oxide with a mixing molar ratio of 1:1 is used as the metal oxide catalyst, and the amount of catalyst added is the total amount of reactants 0.08wt%.

[0029] According to the one-step synthesis method in Example 1, the reaction temperature of the primary mixer is generally controlled between 20 and 30 degrees. Specifically, the temperature of the feed port of the primary mixer is controlled at 20 degrees. The outlet temperature of the device is controlled at 25 degrees; the pH value is maintained at 10. The reaction temperature of the secondary mixer is generally controlled between 30 and 40 degrees. Specifically, the temperature of the inlet of the secondary mixer is controlled at 30 degrees, and the temperature of the outlet of the secondary mixer is controlled at 35 degrees; the pH value is maintained at 10.

[0030] After the reaction w...

Embodiment 3

[0032] The molar ratio of raw materials methyl laurate and sodium glutamate is 1.8:0.7, and the mixture of potassium oxide and magnesium oxide with a molar ratio of 2:1 is used as the metal oxide catalyst, and the amount of the catalyst added is the total amount of reactants 0.05wt%.

[0033] According to the one-step synthesis method in Example 1, the reaction temperature of the primary mixer is generally controlled between 20 and 30 degrees. Specifically, the temperature of the feed port of the primary mixer is controlled at 25 degrees. The outlet temperature of the device is controlled at 25 degrees; the pH value is maintained at 10. The reaction temperature of the secondary mixer is generally controlled between 30 and 40 degrees. Specifically, the temperature of the inlet of the secondary mixer is controlled at 35 degrees, and the temperature of the outlet of the secondary mixer is controlled at 35 degrees; the pH value is maintained at 13 .

[0034] After the reaction w...