The invention belongs to the field of a pharmaceutical preparation, and particularly relates to a mixed
carbohydrate-
electrolyte injection and a preparation method thereof. A pH modifier of the injection is
citric acid, and pH is 4.0-4.4. By controlling the dosage range of the pH modifier, the
pH range of the finished product can meet the specification only by regulating the pH value for one time in the preparation process. In addition, according to the method,
activated carbon is added only in the step, and the
activated carbon is not added in the preparation process, so that the risk of introducing
metal ions and other impurities through the
activated carbon can be effectively avoided, and toxins in
bacteria of the finished product are qualified. According to the method, the technology is further simplified, the production time and cost can be shortened and lowered, and the sterilized product has no
crystallization or
precipitation phenomenon. After being stored for 24 months, the 5-
hydroxymethyl-
furfural range of the injection is within 0.03-0.05, and the impurities are controlled at the extremely low level; after being stored for 24 months, the injection almost has no
character change and is still colorless
clear liquid compared with the injection which is stored for zero day.