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42 results about "Single-use bioreactor" patented technology
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A single-use bioreactor or disposable bioreactor is a bioreactor with a disposable bag instead of a culture vessel. Typically, this refers to a bioreactor in which the lining in contact with the cell culture will be plastic, and this lining is encased within a more permanent structure (typically, either a rocker or a cuboid or cylindrical steel support). Commercial single-use bioreactors have been available since the end of the 1990s and are now made by several well-known producers (See below) .
Single Use Bioreactor
ActiveUS20170349874A1OptimizationImprove operating characteristicsBioreactor/fermenter combinationsBiological substance pretreatmentsEngineeringMammalian cell
A single-use bioreactor is provided. The single-use bioreactor may include a bioprocess container, a shell, at least one agitator, at least one sparger, at least one gas filter inlet port for the sparger(s) and headspace overlay, at least one fill port, at least one harvest port, at least one sample port, and at least one probe. In examples, at least one controller may monitor and control one or more parameters associated with the single-use bioreactor A method to cultivate and propagate mammalian cells is also provided. The method may include cultivating under suitable conditions and in a suitable culture medium in a first single-use bioreactor, transferring the medium containing the cells obtained by propagation from the at least one mammalian cell is into a second single-use bioreactor, transferring the medium containing the cells obtained by propagation from the at least one mammalian cell is into a third single-use bioreactor, and cultivating the cells in the third bioreactor.
Owner:LONZA LTD
Disposable Bio-Reactor System
InactiveUS20110014689A1Improve cell culture technologyBioreactor/fermenter combinationsShaking/oscillating/vibrating mixersReactor systemEngineering
A disposable bioreactor system with a focus on improving cell culture technology by introducing a disposable bioreactor bag which operates or functions in conjunction with a unique mechanism of external non-rotating gyrating motion that uses gravity in a natural way to make the fluid flow circumferentially in it. The bioreactor is eminently suitable to grow a variety of living cells and has the advantage of tangential flow to avoid clogging of filters.
Owner:LABLINKS BIOTECH PVT
Composite sensor assemblies for single use bioreactors
ActiveUS20120244609A1Bioreactor/fermenter combinationsBiological substance pretreatmentsElectricityThermoplastic
A composite sensor assembly for monitoring bio-processes which is suitable for use with a polymeric bioprocess vessel or with downstream equipment, and comprises:i) a port comprising a high surface tension thermoplastic having a hollow tubular portion and a base plate portion, the base plate portion being fusibly sealable to the bioreactor vessel at a hole in the wall thereof;ii) a generally opaque polymeric monitoring sensor assembly including electrical, and / or optical measurement components. The sensor assembly fits inside the bore of the hollow tubular portion of the port, and is adhesively retained therein.
Owner:FINESSE SOLUTIONS
Bioreactor With Higher Agitation Rates
InactiveUS20180010082A1OptimizationImprove operating characteristicsBioreactor/fermenter combinationsBiological substance pretreatmentsEngineeringMammalian cell
A single-use bioreactor is provided. The single-use bioreactor may include a bioprocess container, a shell, at least one agitator, at least one sparger, at least one gas filter inlet port for the sparger(s) and headspace overlay, at least one fill port, at least one harvest port, at least one sample port, and at least one probe. In examples, at least one controller may monitor and control one or more parameters associated with the single-use bioreactor A method to cultivate and propagate mammalian cells is also provided. The method may include cultivating under suitable conditions and in a suitable culture medium in a first single-use bioreactor, transferring the medium containing the cells obtained by propagation from the at least one mammalian cell is into a second single-use bioreactor, transferring the medium containing the cells obtained by propagation from the at least one mammalian cell is into a third single-use bioreactor, and cultivating the cells in the third bioreactor.
Owner:LONZA LTD
Bioreactors
InactiveUS20110151551A1Prevent and minimize formationContour smoothingBioreactor/fermenter combinationsBiological substance pretreatmentsWrinkle skinEngineering
The present invention relates to improved single-use bioreactors comprising disposable plastic bags for cell cultivation. The invention provides an inflatable bioreactor bag for cell cultivation comprised of a top and a bottom sheet of polymer material that are joined along their edges to form a sealed bag, wherein two opposing edges are formed as clamping edges to allow clamping of the bioreactor bag to a rocker type bioreactor, and wherein the bioreactor bag is provided with a wrinkle preventing structure at each end of the clamping edges. The bag avoids formation of undesired wrinkles or creases which otherwise lead to fatigue of the plastic and eventually fracture.
Owner:GE HEALTHCARE BIO SCI CORP
Linearly scalable single use bioreactor system
ActiveUS20130288346A1Eliminate needRisk minimizationBioreactor/fermenter combinationsBiological substance pretreatmentsImpellerBiomanufacturing
Disclosed is a single-use bioreactor bag design providing substantially equivalent maximum shear rate at the impeller tip and average or bulk shear rate over a range of power per unit working volume and rpm needed for bioculture processing. The uniformity in shear profile of the bag design providing a unique advantage when used as a scale-down or scale-up platform. Also disclosed is a linearly scalable, single-use, bioreactor system for use in carrying out a scalable biomanufacturing process, the system comprising two single-use bioreactor bags of different volumes, wherein the ratio H / D of the height of the working volume H to the diameter D of the tank, or of the bag is equal to about 1.5, and the bulk shear in each of the bags is substantially constant. The disclosed small scale system models larger scale systems from both a shear / scalability / performance basis and also from a validation and regulatory basis. In summary, the 10 L bioreactor system disclosed provides for “linear scalability” by using the same or substantially simulating the same vessel geometry, gas sparging system, impeller shape and type, polymer composition of the flexible bag / components, process control system, and shear rates as larger 50-5000 L systems.
Owner:GLOBAL LIFE SCI SOLUTIONS USA LLC
Composite sensor assemblies for single use bioreactors
ActiveUS20120244608A1Reduce usageHigh densityBioreactor/fermenter combinationsBiological substance pretreatmentsThermoplasticElectricity
A composite sensor assembly for monitoring bio-processes which is suitable for use with a polymeric bioprocess vessel or with downstream equipment, and comprises:i) a port comprising a high surface tension thermoplastic having a hollow tubular portion and a base plate portion, the base plate being fusibly sealable to the bioreactor vessel at a hole in the wall thereof;ii) a generally opaque polymeric monitoring sensor assembly including electrical, and / or optical measurement components. The sensor assembly fits inside the bore of the hollow tubular portion of the port, and is adhesively retained therein.
Owner:FINESSE SOLUTIONS
Composite sensor assemblies for single use bioreactors
ActiveUS9267100B2Bioreactor/fermenter combinationsBiological substance pretreatmentsThermoplasticEngineering
Owner:FINESSE SOLUTIONS
Multipurpose bioreactor
InactiveUS20170198246A1Increase variabilityHigh yieldBioreactor/fermenter combinationsBiological substance pretreatmentsBiologySingle-use bioreactor
A multiuse bioreactor that is a single-use bioreactor, a development bioreactor, a commercial manufacturing bioreactor, a batch, a fed-batch, a perfusion and continuous bioreactor, a convective heat bioreactor, a product capture bioreactor, an ISO 9 bioreactor, a eukaryotic bioreactor, a prokaryotic bioreactor, a technology transfer-free bioreactor, and an inexpensive bioreactor is disclosed.
Owner:NIAZI SARFARAZ K
Biotechnological apparatus comprising a bioreactor, exhaust gas temperature control device for a bioreactor and a method for treating an exhaust gas stream in a biotechnological apparatus
ActiveUS20140329224A1Easy to handleEasy to operateBioreactor/fermenter combinationsBiological substance pretreatmentsTemperature controlSingle-use bioreactor
This patent document relates to the field of biotechnological apparatuses. It relates particularly to a biotechnological apparatus comprising a bioreactor, an exhaust gas temperature control device and a method for treating an exhaust gas stream. This patent document further relates to a connection device for a sterile single-use fluid conduit of a single-use bioreactor and to a method for treating a fluid stream. The reusable connection device comprises a receptacle in which a portion of the fluid conduit can be detachably arranged, and a coupling member connecting the connection device to a temperature control device, the receptacle having a contact surface which is arranged such that the contact surface abuts a fluid conduit arranged in the receptacle, and wherein a portion of a fluid conduit can be introduced into the receptacle in a direction running substantially orthogonally to a longitudinal axis of the connection device.
Owner:DASGIP INFORMATION & PROCESS TECH
Pneumatically agitated and aerated single-use bioreactor
InactiveUS20120252108A1Well mixedAvoid componentsBioreactor/fermenter combinationsBiological substance pretreatmentsImpellerEngineering
A single-use round flexible mixing bag for use in bioprocessing in which a fluid is received and agitated using an internal fluid-agitating element comprising a radial flow impeller driven by an internal pneumatic vane motor is disclosed. The bag may include an integral sparger and sensor receiver. Related methods are also disclosed.
Owner:ADELLO BIOLOGICS LLC
pH sensor integration to single use bioreactor/mixer
ActiveCN103339248ABioreactor/fermenter combinationsBiological substance pretreatmentsElectrolytic agentPhysical chemistry
A pH sensing bioreaction system is provided. The system includes a bioreaction container (51) having a plastic wall (50) and a pH sensor (40, 60, 80, 100, 120) attached to the plastic wall (50). The pH sensor (40, 60, 80, 100, 120) includes a sensor body (82) having a flange (76) that is sealingly attached to the plastic wall (50). The sensor body (82) has a reference electrolyte (142) therein and a first sensing element (152) disposed in the reference electrolyte (142). The first sensing element (152) is configured to contact both the reference electrolyte (142) and a sample solution (52) inside the bioreaction container. A second sensing element (62, 92, 148) is positionable into an interior of the bioreaction container (51). The pH sensor (40, 60, 80, 100, 120) has a plurality of configurations that include a booted configuration in which at least one sensing element is isolated from the interior of the bioreaction container (51), and a service configuration in which the at least one sensing element is fluidically coupled to the interior of the bioreaction container (51).
Owner:ROSEMOUNT INC
Single-use bioreactor and head plate, and a process for manufacturing same
ActiveUS20150132840A1Sterility of can not be compromisedBioreactor/fermenter combinationsBiological substance pretreatmentsRotational axisEngineering
A single-use bioreactor, suitable in particular for use in a parallel bioreactor system for applications in cell culture and / or microbiology, a head plate for such a single-use bioreactor and a process for manufacturing the single-use bioreactor and the head plate. The single-use bioreactor comprises a head plate, a dimensionally stable container and a mixer, the head plate and the container enclosing a reaction chamber, and the mixer having a mixer shaft and a stirring member, said mixer shaft being mounted rotatably about a rotational axis in a bearing and the stirring member being fastened torsionally rigidly to the mixer shaft. The mixer and the bearing are arranged entirely within the reaction chamber and the mixer shaft has a magnetic portion which is arranged and adapted in such a way that it can be coupled magnetically in an axial direction to a rotary drive.
Owner:EPPENDORF SE
Cell culture composite film and preparation method and application thereof
InactiveCN109878184ASynthetic resin layered productsTissue/virus culture apparatusComposite filmBiocompatibility Testing
The invention relates to a cell culture composite film and a preparation method and application thereof. The cell culture composite film comprises a core layer, a first binding layer, an oxygen-resisting layer, a second binding layer and an anti-abrasion outer layer which are sequentially bonded from inside to outside, and is prepared through technologies such as multilayer co-extrusion or embedding or lamination; and the film prepared through the method can be used for manufacturing various single-use bioreactors, storage containers and transferring containers for cell culture, and has very little dissolved matter and educt, great biocompatibility and very low cytotoxicity, a selected core layer material is biodegradable, the production method is simple, the cost is low, and the cell culture composite film is an environment-friendly polymer thin film material and is particularly suitable for the biopharmaceutical industry.
Owner:杭州九龄科技有限公司
Shaft-Mounted Fluid Transfer Assembly for a Disosable Bioreactor
ActiveUS20170362555A1Bioreactor/fermenter combinationsBiological substance pretreatmentsImpellerEngineering
A fluid transfer assembly for single use bioreactors includes a fluid transfer housing that can be mounted to the impeller shaft using a bearing that places the fluid transfer assembly directly below the lowest impeller but allows the impeller shaft to spin inside independently of the fluid transfer assembly. A fluid conduit connects the fluid transfer housing to a port in the single use bag wall which allows fluids to be introduced into the sparger and which also helps prevent the fluid transfer assembly from rotating with the impeller shaft.
Owner:GLOBAL LIFE SCI SOLUTIONS USA LLC
Unitary plastic conductivity sensor
A contacting-type conductivity sensor (10) includes an electrically-insulative plastic body (20) and a plurality of electrodes (12, 14, 16, 18). The plurality of conductive electrodes (12, 14, 16, 18) is disposed in the plastic body (20). Each electrode (12, 14, 16, 18) is constructed of plastic and fused with the electrically-insulative plastic body (20). A method of manufacturing the conductivity sensor is provided along with a single-use bioreactor (50) employing the sensor (10).
Owner:ROSEMOUNT INC
Passive automatic antifoam delivery system for use with single-use bioreactors
PendingCN107922905ABioreactor/fermenter combinationsBiological substance pretreatmentsEngineeringDelivery system
The aspects of the disclosed embodiments generally relate to an apparatus which allows for the controlled addition of antifoam to the foam present in the headspace of a disposable single-use bioreactor in a reliable manner. The aspects of the disclosed embodiments also generally relate toa method of using such apparatus which allows for the controlled addition of antifoam to the foam present in the headspace of a disposable single-use bioreactor in a reliable manner. The aspects of the disclosed embodiments generally relate to antifoam systems, methods and apparatus, and more particularly, toan antifoam device operably connected to a single use biobag.
Owner:GLOBAL LIFE SCI SOLUTIONS USA LLC
Composite sensor assemblies for single use bioreactors
InactiveUS20160130548A1Bioreactor/fermenter combinationsBiological substance pretreatmentsThermoplasticPhysical chemistry
Owner:FINESSE SOLUTIONS
Composite sensor assemblies for single use bioreactors
ActiveUS10227555B2Reduce usageHigh densityBioreactor/fermenter combinationsBiological substance pretreatmentsElectricityThermoplastic
Owner:FINESSE SOLUTIONS
Pneumatically agitated and aerated single-use bioreactor
InactiveUS9339026B2Prevent dead spotWell mixedBioreactor/fermenter combinationsBiological substance pretreatmentsImpellerEngineering
A single-use round flexible mixing bag for use in bioprocessing in which a fluid is received and agitated using an internal fluid-agitating element comprising a radial flow impeller driven by an internal pneumatic vane motor is disclosed. The bag may include an integral sparger and sensor receiver. Related methods are also disclosed.
Owner:ADELLO BIOLOGICS LLC
Support vessels for single use bioreactors and mixers
PendingUS20190194589A1Easy to assembleReduce manufacturing costBioreactor/fermenter combinationsBiological substance pretreatmentsInterior spaceEngineering
The invention discloses a hollow profile wall segment (1) for a bioreactor or mixer support vessel (2;2a;2b), comprising a base profile (3) with two parallel wide sides (4,5), two narrow sides (6,7) and at least one heat exchange channel (8) extending in a longitudinal direction of the base profile through an interior space (9) in the base profile, wherein the hollow profile wall segment is adapted to be joined with similar hollow profile wall segments to form a side wall (12) of a bioreactor or mixer support vessel (2) and wherein each narrow side comprises at least one coupling member (10,11;11a;150) capable of securing the hollow profile wall segment side by side with similar hollow profile wall segments.
Owner:CYTIVA SWEDEN AB
Reinforced bioreactor component structure system for cell cultivation
InactiveUS20210016287A1Avoid crimpingAdd featureBioreactor/fermenter combinationsBiological substance pretreatmentsEngineeringBiochemistry
The present invention involves a reinforced tubing structure that is particularly useful for reinforcing tubing that is present inside disposable bioreactor bags, including for example thermowell tubing.
Owner:GE HEALTHCARE BIO SCI CORP
Disposable bioprocess system supporting biological activity
PendingCN108350405ABioreactor/fermenter combinationsBiological substance pretreatmentsLiquid mediumEngineering
The present invention relates to a Disposable Bioprocess System consisting of a Single-Use-Bioreactor, a Single-Use-Pump and a single-use micro-organism retention filter. The system is combined most suitable for cultivation of suspended micro-organisms in a liquid media at high micro-organism concentration in a perfusion mode continuous process for expression of biological material. The inlet portof the liquid Single-Use-Pump connects via a valve to the broth reservoir of the Single-Use-Bioreactor through a liquid conveying port. The outlet port of the liquid pumping Single-Use-Pump connectsvia a valve to a micro-organism retention filter. And a method for operating said sterile Disposable Bioprocess System in perfusion mode for continuously processing.
Owner:特定瑞士股份有限公司
Cost-effective Raman probe assembly for single-use bioreactor vessels
ActiveUS10261020B2Low costAccurate locationBioreactor/fermenter combinationsRadiation pyrometryEngineeringSpectral signature
Systems and methods are used to couple an optical sampling probe to a port in a single-use bioreactor bag for in-process monitoring. A combination of re-useable and disposable components maintain precision while reducing costs. A disposable barb with an integral window, received by the port of the reaction vessel, is coupled to a re-useable optic component with a focusing lens. A separate focus alignment tool is used to set the lens position to a precise focal point before placement of the optic component into the barb. The fixture includes a window to simulate the window in a barb component, a target with a known spectral signature, and a probe head coupled to a spectral analyzer. The axial position of the lens is adjusted with respect to the spacer component to maximize the spectral signature from a sample target, whereupon the spacer component is bonded to the lens mount.
Owner:ENDRESS + HAUSER OPTICAL ANALYSIS INC
Single use bioreactor
ActiveUS10801003B2OptimizationImprove operating characteristicsBioreactor/fermenter combinationsBiological substance pretreatmentsMicrobiologyCultured cell
A single-use bioreactor is provided. The single-use bioreactor may include a bioprocess container, a shell, at least one agitator, at least one sparger, at least one gas filter inlet port for the sparger(s) and headspace overlay, at least one fill port, at least one harvest port, at least one sample port, and at least one probe. In examples, at least one controller may monitor and control one or more parameters associated with the single-use bioreactor A method to cultivate and propagate mammalian cells is also provided. The method may include cultivating under suitable conditions and in a suitable culture medium in a first single-use bioreactor, transferring the medium containing the cells obtained by propagation from the at least one mammalian cell is into a second single-use bioreactor, transferring the medium containing the cells obtained by propagation from the at least one mammalian cell is into a third single-use bioreactor, and cultivating the cells in the third bioreactor.
Owner:LONZA LTD
pH sensor combined with single use bioreactor/mixer
ActiveCN103339248BBioreactor/fermenter combinationsBiological substance pretreatmentsElectrolytic agentEngineering
Owner:ROSEMOUNT INC
Multi-chamber bioreactor apparatus
ActiveUS20200032185A1Reduce the risk of contaminationEliminate needBioreactor/fermenter combinationsBiological substance pretreatmentsEngineeringMechanical engineering
A multi-chamber single-use bioreactor for cell culture expansion has bag assembly and a rigid support structure defining a bag receiving space. The bag assembly disposed in the bag receiving space of the rigid support structure and supported by the rigid support structure. The bag assembly has at least a first flexible bag and a second flexible bag. The first bag defines a first reaction chamber, and the second bag defines a second reaction chamber. The first reaction chamber has a first volume, a first inlet, and a first outlet, and the second reaction chamber has a second volume different from the first volume, a second inlet, and a second outlet. The second inlet of the second bag is fluidically connected to the first outlet of the first bag so liquid in first reaction chamber can be transferred to the second reaction chamber.
Owner:BOARD OF REGENTS FOR OKLAHOMA STATE UNIVERSITY
Split sensor and housing assembly for flexible wall
ActiveUS20130196361A1Reduce in quantityBioreactor/fermenter combinationsBiological substance pretreatmentsEngineeringSingle-use bioreactor
Disclosed is a sensor and housing assembly for a single-use bioreactor system, including a device for operatively associating a sensor with a flexible wall, the device comprising an internal housing portion that is removable and variably positionable on an internal surface of the flexible wall, the internal housing portion comprising a chemical detector sensor, which may be an optical chemical detector sensor.
Owner:GLOBAL LIFE SCI SOLUTIONS USA LLC
Single-use bioreactor sensor architecture
InactiveCN105115539ABiochemistry apparatusMaterial analysisSingle-use bioreactorElectrical and Electronics engineering
A sensor assembly includes a first sensor and a second sensor. An enclosure is operably coupled to each of the first and second sensors and contains memory that stores compensation data for each of the first and second sensors. A connector is operably coupled to the first and second sensors. A bioreaction sensing assembly as well as a method of manufacturing the bioreaction sensing assembly is also provided.
Owner:ROSEMOUNT INC
Modified polymer film surfaces for single-use bioreactor bags and biocontainment and methods of forming same
PendingUS20210317278A1Bioreactor/fermenter combinationsBiological substance pretreatmentsPolyethylene vinyl acetateAcetic acid
In some embodiments, a polymer film includes a base composition of poly(ethylene-vinyl acetate) and a surface composition comprising hydroxy groups. In some embodiments, a polymer film includes a base layer of a first composition of poly(ethylene-vinyl acetate), a surface layer at a surface of the base layer, and a coating layer of a second composition of a copolymer of glycerol and sebacic acid. The surface layer includes surface hydroxy groups converted from acetate groups of the poly(ethylene-vinyl acetate). The second composition is attached to the surface layer by ester bonds between carboxyl groups of the copolymer and the hydroxy groups. A single-use bioreactor bag includes a polymer film including a base composition of poly(ethylene-vinyl acetate) and a surface composition comprising hydroxy groups. A method of modifying a poly(ethylene-vinyl acetate) film includes converting acetate groups at a first surface of the poly(ethylene-vinyl acetate) film to hydroxy groups.
Owner:THE SECANT GRP
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