The invention discloses a fresh pericarpium zanthoxyli
oleoresin separation and purification process which comprises the following steps: after harvesting fresh pericarpium zanthoxyli, carrying out cold pressing within two hours to obtain fresh pericarpium zanthoxyli
oleoresin, carrying out countercurrent extraction separation on the fresh pericarpium zanthoxyli
oleoresin through a liquid substance extraction and separation unit of a supercritical CO2 fluid dynamic countercurrent extraction and
separation system, and after the countercurrent extraction separation is completed, obtaining fresh pericarpium zanthoxyli resin from the extraction unit, and obtaining fresh pericarpium zanthoxyli
essential oil through a separation unit. The extraction
separation process is as follows: the feeding rate is 40kg / h, the CO2 flow rate is 600L / h, the extraction temperature is 45 DEG C, and the extraction pressure is 20MPa; the separation I temperature is 40 DEG C, the separation I pressure is 7.5 MPa, the separation II temperature is 55 DEG C, and the separation II pressure is 4-6 MPa; the total yield of the oleoresin product reaches 98.74%-99.17%, and the separation efficiency of volatile oil reaches 94.00%-99.24%; the volatile
oil content of the obtained
essential oil can reach 101.94-128.93 ml / 100g; the content of
amide substances in the obtained resin can reach 575.22 mg / g to 645.99 mg / g, and the content of the
amide substances is increased to 79.08% to 98.25%. According to the process disclosed by the invention, the fresh pericarpium zanthoxyli
essential oil with high volatile
oil content and the fresh pericarpium zanthoxyli resin with a high
amide substance content can be obtained, and the purification effect of the two products is remarkable.