The invention discloses a purification method of cefazolin sodium, and relates to the technical field of purification of cefazolin sodium. The method comprises the following steps: (1) after cefazolinis synthesized, adding water for hydrolysis, adding dichloromethane into hydrolysate, then adding hydrochloric acid, controlling the pH value to be 1.3-1.6, standing, carrying out phase splitting, discarding a water phase, and collecting a dichloromethane phase; and (2) adding water into the dichloromethane phase, adjusting the pH value to 6.4-6.7 by using a sodium hydroxide solution, standing, carrying out phase splitting, and discarding the dichloromethane phase to obtain a purified cefazolin sodium solution. The method disclosed by the invention is simple and convenient to operate, short in period and less in wastewater discharge, and has the advantage of environmental protection, and the product cefazolin sodium is high in content, less in impurity variety, low in impurity content andsafe to use as medicine.