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Calcium orthophosphate bone cement/PLGA /brizolina natrium compound material and method of preparing the same

A technology of calcium phosphate bone cement and cefazolin sodium, which is used in medical science, prosthesis and other directions, can solve the problems of low strength, decreased strength of calcium phosphate bone cement, poor mechanical properties, etc., and achieves high mechanical properties and controlled drug release. Effect

Inactive Publication Date: 2008-08-27
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Over the years, in the process of research and application of calcium phosphate bio-bone cement, the problems of low strength and poor mechanical properties of this type of material have been prominent, limiting its application range
However, the loading of antibiotics, especially a large amount of antibiotics will lead to a significant decrease in the strength of calcium phosphate bone cement

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 1) 8g of calcium phosphate bone cement (purchased from Shanghai Ruibang Biomaterials Co., Ltd.) and 1.6g of PLGA (polylactic acid: polyglycolic acid = 75:25, intrinsic viscosity 0.4-0.6) were mixed evenly by dry ball milling, and ball milling The speed is 300 rpm, and the ball milling time is 40min;

[0024] 2) dissolving the antibiotic cefazolin sodium in a ratio of 1g / 4ml in deionized water to make a blend;

[0025]3) Add the blending solution prepared in step 2) to the mixed powder described in step 1), the addition amount is calculated according to the ratio of 0.40ml / g, and then fully mix to obtain bone cement paste;

[0026] 4) Pour the uniformly mixed bone cement slurry in step 4) into the set mold, exhaust and shake it flat to make a flat sample;

[0027] 5) Put the sample in a constant temperature box with a temperature of 37° C. and a humidity of 100%, and keep it warm for 24 hours to obtain the set calcium phosphate bone cement biocomposite material.

[002...

Embodiment 2

[0030] 1) Mix 8 g of calcium phosphate bone cement (purchased from Shanghai Ruibang Biomaterials Co., Ltd.) and 1.0 g of PLGA (polylactic acid: polyglycolic acid = 75:25, intrinsic viscosity 0.4-0.6) by dry ball milling, and ball mill The speed is 250 rpm, and the ball milling time is 60 min.

[0031] 2) The antibiotic cefazolin sodium was dissolved in deionized water at a ratio of 0.1g / 4ml to prepare a blend solution.

[0032] 3) Add the bone cement blend prepared in step 2 to the mixed powder described in step 1, and the amount added is 0.4ml / g.

[0033] 4) Mix the bone cement slurry obtained in step 4 evenly, pour it into the set mold, exhaust and shake it flat, and make a flat sample;

[0034] 5) Place the sample in a so-called incubator with a temperature of 37° C. and a humidity of 100%, and keep it warm for 24 hours to obtain the corresponding calcium phosphate bone cement biocomposite material.

[0035] It has been determined that the main performance of the calcium ...

Embodiment 3

[0037] 1) 8g of calcium phosphate bone cement (purchased from Shanghai Ruibang Biomaterials Co., Ltd.) and 2.0g of PLGA (polylactic acid: polyglycolic acid = 50:50, intrinsic viscosity 0.5-0.7) were mixed evenly by dry ball milling. The speed is 280 rpm, and the ball milling time is 50 min.

[0038] 2) the antibiotic cefazolin sodium is dissolved in deionized water according to the ratio of 0.5g / 4ml to make a blend;

[0039] 3) Add the blending solution prepared in step 2) to the mixed powder described in step 1), the addition amount is calculated according to the ratio of 0.40ml / g, and then fully mix to obtain bone cement paste;

[0040] 4) Pour the bone cement slurry uniformly mixed in step 4) into the set mold, exhaust and shake it flat to make a flat sample;

[0041] 5) Put the sample in a constant temperature box with a temperature of 35° C. and a humidity of 100%, and keep it warm for 36 hours to obtain the set calcium phosphate bone cement biocomposite material.

[00...

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Abstract

The invention discloses a calcium phosphate cement virgule PLGA virgule cefazolin sodium composite material and a preparation method thereof. The method uses dry ball milling to mix calcium phosphate cement and polyglycolic-polyactic acid, dissolves antibiotics into deionized water to prepare distiller liquor, mixes the antibiotics and the deionized water according to the set solid-liquid ratio, and forms artificial bone activity material, namely calcium phosphate cement virgule PLGA virgule cefazolin sodium composite. The method solves the problem of low strength of bone cement loading with a large quality of antibiotics effectively, improves the biological compatibility, degradability, and degradation tunability of polyglycolicacid, and acheives the aim of controlling medical release and the growth of the induced bone after polyglycolic acid degradation.

Description

technical field [0001] The invention relates to a calcium phosphate bone cement composite material and its preparation, in particular to a calcium phosphate bone cement (CPC) / polylactic acid-polyglycolic acid (PLGA) / cefazolin sodium composite material and a preparation method thereof. Background technique [0002] In the field of bone repair materials, biocompatible calcium phosphate bone cement, which can be shaped arbitrarily and can quickly self-cure under body fluid conditions, has become an important content of biomedical engineering research. Calcium phosphate cement (CPC) has played an important role in the field of bone defect repair due to its good biocompatibility, osteoconductivity and degradability since its birth. And other shortcomings, so that its application is subject to certain restrictions. In recent years, with the continuous improvement of CPC modification research, its performance has been continuously improved, and some new and improved CPC materials ...

Claims

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Application Information

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IPC IPC(8): A61L27/42A61L27/18A61L27/12A61L27/54
Inventor 李轩琦孙康宁李春胜王爱娟孙晓宁冷亮
Owner SHANDONG UNIV
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