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Beta-lactam antibiotic multi-template molecularly imprinted magnetic composite material, preparation method and application thereof

A technology of magnetic composite materials and lactams, applied in chemical instruments and methods, other chemical processes, etc., to achieve the effect of increasing specific surface area, large adsorption capacity, and avoiding accumulation

Active Publication Date: 2021-03-26
GUANGDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention provides a β-lactam antibiotic multi-template molecularly imprinted magnetic composite material and its preparation method and application, which solves the difficulty of single-template imprinted polymers at present. Simultaneously efficient adsorption and separation of multiple BLAs

Method used

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  • Beta-lactam antibiotic multi-template molecularly imprinted magnetic composite material, preparation method and application thereof
  • Beta-lactam antibiotic multi-template molecularly imprinted magnetic composite material, preparation method and application thereof
  • Beta-lactam antibiotic multi-template molecularly imprinted magnetic composite material, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] (1) Take 5.0g graphite powder, 2.5gNaNO 3 , under the conditions of mechanical stirring and ice-water bath (<10°C), mix it in 250mL of concentrated sulfuric acid, then slowly add 35g of potassium permanganate powder, keep the temperature below 10°C, and react for 2h. Then the temperature was raised to 35°C, and the reaction was carried out for 2h. Afterwards, 240 mL of deionized water was added dropwise, while the reaction temperature was set at 90° C., and the reaction was carried out for 40 minutes when the reaction temperature reached 90° C. After the reaction, cool to room temperature, add 1000mL of deionized water to dilute, then add 30mL of 30% hydrogen peroxide, let stand to precipitate and separate layers. Then, the precipitate was washed with 10-fold diluted hydrochloric acid solution for several times until the supernatant was collected by centrifugation and added with sodium hydroxide solution without producing black precipitate. Finally, the precipitate wa...

Embodiment 2

[0069] Performance tests were performed on the β-lactam antibiotics multi-template molecularly imprinted magnetic composites (MIPs) prepared in Example 1.

[0070] (1) Get 20 mg of MIPs prepared in Example 1 and the composite material NIPs of Comparative Example 1 without molecular imprinting and add 20 ml respectively, 50 mg / L of BLAs (cephalexin, cefazolin sodium, penicillin G sodium, oxacillin Sodium and amoxicillin in the BLAs solution with a molar ratio of 1:1:1:1:1) were adsorbed by shaking at 25°C and 150r / min for 2h, and the concentrations of the solutions before and after adsorption were measured respectively to obtain MIPs and NIPs For the adsorption amount of BLAs, at the same time, the ratio analysis of the adsorption amount of the two was carried out to obtain the imprinting factor.

[0071] The results showed that under the condition of initial concentration of 50 mg / L, the magnetic composite imprinted material (MIPs) could adsorb amoxicillin, cephalexin, cefazol...

Embodiment 3

[0086] The MIPs prepared in Example 1 were tested for removal of β-lactam antibiotics in water samples.

[0087] (1) Take amoxicillin, cephalexin, cefazolin, oxacillin, and penicillin G analytical standard 10mg respectively, dissolve them in a mixed solution of chromatographic acetonitrile: ultrapure water volume ratio 1:1, and dilute to 100mL A 100 mg / L standard stock solution was prepared in a volumetric flask, and then serially diluted with deionized water to obtain a BLAs spiked simulated water sample with a concentration of 50 μg / L.

[0088] (2) Take 20 mg of the MIPs prepared in Example 1, take 20 mL of spiked simulated water sample, and carry out the shock adsorption experiment at room temperature and 150 r / min. The adsorption time is 120 min. The remaining concentration in the simulated water sample was measured by liquid chromatography, and the removal rate of BLAs by the material was obtained by comparing the concentration of the water sample before adsorption.

[0...

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Abstract

The invention relates to the technical field of adsorption materials, in particular to a beta-lactam antibiotic multi-template molecularly imprinted magnetic composite material, a preparation method and application thereof. The invention discloses a beta-lactam antibiotic multi-template molecularly imprinted magnetic composite material, which has strong adsorption selectivity, can specifically andquickly adsorb cefalexin, cefazolin sodium, penicillin G sodium, oxacillin sodium and amoxicillin, and has large adsorption capacity. The composite material also shows superparamagnetism, solid-liquid separation can be rapidly and effectively realized, and the working efficiency is improved. The composite material can be combined with high performance liquid chromatography to be used for detecting the beta-lactam antibiotics in a complex environment water sample, and the beta-lactam antibiotics in the complex environment water sample can be effectively detected and separated.

Description

technical field [0001] The invention relates to the technical field of adsorption materials, in particular to a β-lactam antibiotic multi-template molecularly imprinted magnetic composite material and its preparation method and application. Background technique [0002] β-lactam antibiotics (BLAs) are one of the most widely used antibiotic drugs in the past 80 years. They are widely used in human and animal diseases because of their strong bactericidal activity, low toxicity and wide indications. prevention and treatment. There are two main classes: penicillins and cephalosporins. Typical BLAs include amoxicillin (AMOX), oxacillin (OXA), penicillin (PENG), cephalexin (CFX), cefazolin (CFZ) and so on. China is the country with the largest production and consumption of antibiotics in the world. The long-term use and even abuse of antibiotics have led to a large amount of antibiotics being directly discharged into the environment. Compared with the hazards of COD, nitrogen, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/28C08G77/26C08K9/10C08K9/12C08K9/04C08K3/04C08K3/22B01J20/26B01J20/30C08L83/08
CPCC08J9/28C08G77/26C08K9/10C08K9/12C08K9/04C08K3/042C08K3/041C08K3/22B01J20/268C08J2201/0424C08K2003/2275C08J2383/08
Inventor 马晓国王颖彭雨琦
Owner GUANGDONG UNIV OF TECH
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