Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of cefazolin sodium

A technology of cefazolin sodium and cefazolin, which is applied in the field of preparation of pharmaceutical compounds, can solve the problems of environmental pollution, complicated process, and low yield, and achieve the effects of high recovery rate, simple process, and simple recovery

Active Publication Date: 2012-01-18
哈药集团股份有限公司 +1
View PDF3 Cites 20 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The above methods are complex in process, difficult in operation, low in yield and pollute the environment

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of cefazolin sodium
  • Preparation method of cefazolin sodium
  • Preparation method of cefazolin sodium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Step 1, three-position intermediate (TDA) of cefazolin sodium is synthesized

[0042] Add 500g of dimethyl carbonate and 500g of boron trifluoride-dimethyl carbonate solution into the condensation reaction bottle and stir, then put 150g of thiadiazole and 300g of 7-ACA into the reaction bottle, and raise the temperature at the same time, the reaction temperature is 35-40°C , reacted until the residue of 7-ACA was less than 1.0%. After the reaction is complete, transfer the reaction solution into a crystallization bottle containing 3000ml of deionized water and 500ml, add ammonia water dropwise to pH 2-4, cool down to 10°C, and stir for 1 hour to grow crystals. Filter, wash the material with acetone until the material liquid is colorless and drain, and put the wet product into the next step.

[0043] Step 2, cefazolin acid synthesis

[0044] Add 80g of tetrazolium acetic acid to 1000ml of dichloromethane, cool down to -50±1°C, add 120ml of triethylamine dropwise within...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a preparation method of a pharmaceutical compound, in particular relates to a preparation method of cefazolin sodium. The preparation method provided by the invention comprises the following steps: step 1, synthesizing TDA (toluene diamine); step 2, synthesizing cefazolin; and step 3, synthesizing cefazolin sodium.

Description

Technical field: [0001] The invention relates to the preparation of a pharmaceutical compound, in particular to the preparation of cefazolin sodium. Background technique: [0002] Cefazolin Sodium [0003] English name: Cefazolin Sodium (Cefamezin) [0004] Alias: Pioneermycin Ⅴ, cephalosporin Ⅴ, cephalosporin, cifazoline, cephalosporin oxazoline, cephalosporin, Kaifuzhuo, Pioneer 5. [0005] Chemical name: (6R,7R)-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)sulfur]methyl]-7-[(1H-tetrazole-1- Base) Acetylamino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt. [0006] Molecular formula: C14H13N8NaO4S3. [0007] Molecular weight: 476.48. [0008] Properties: White or off-white crystalline powder, almost odorless, bitter taste. 1.05g of this product is approximately equivalent to 1g of cefazolin base. 1g of this product contains about 2.1mmol (2.1mEq) of sodium ion. [0009] This product is easily soluble in water, and the pH value of 10% aqueous soluti...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D501/36C07D501/04C07D501/12
Inventor 吴志军余威杨新春陶树青
Owner 哈药集团股份有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com