Cefazolin sodium compound prepared according to novel intelligent crystallization technology and preparation of cefazolin sodium compound

Abstract

The invention discloses a cefazolin sodium compound prepared according to a novel intelligent crystallization technology and a preparation of the cefazolin sodium compound. 'Research, development and industrialization projects of high-end medical product refined crystallization technologies' won second prize of 2015th National Science and Technology Progress Award, and the novel intelligent crystallization technology is among the high-end medical product refined crystallization technologies. The cefazolin sodium compound is determined through X-ray powder diffraction, and main characteristic peaks represented by diffraction angles 2theta in an atlas are 12.24+-0.2 degrees, 16.23+-0.2 degrees, 18.94+-0.2 degrees, 19.26+-0.2 degrees, 19.80+-0.2 degrees, 20.61+-0.2 degrees, 21.05+-0.2 degrees and 23.57+-0.2degrees. Cefazolin sodium is recrystallized by combining a supercritical fluid extraction technology with a traditional crystallization technology. In a whole crystallization system, the process including extraction, adsorption, crystallization and drying is completed to recrystallize the cefazolin sodium at a specific temperature and at specific pressure under the joint action of supercritical fluid, a solvent, an extraction pond and a crystallizing pond. The preparation technology is high in separation efficiency with few impurities, so that preparation product quality is greatly improved.

Description

technical field

[0001] The invention relates to a cefazolin sodium compound prepared by a novel intelligent crystallization technology and a preparation thereof, belonging to the technical field of medicine. Background technique

[0002] The R&D and industrialization project of refined crystallization technology for high-end pharmaceutical products of one of the inventors, Tianjin University and Xi'an Lijun Pharmaceutical Co., Ltd., won the second prize of the 2015 National Science and Technology Progress Award.

[0003] The new intelligent crystallization technology belongs to one of the refined crystallization technologies for high-end pharmaceutical products. It aims to break through the blockade of related pharmaceutical product crystal forms and crystallization technology patents at home and abroad, and realize a leap in the level of high-end pharmaceutical product research and development and crystallization technology. The international leading level has promoted the s...

Images