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Composition of cefazolin sodium pentahydrate and sulbactam sodium

A technology of cefazolin sodium and sulbactam sodium, which is applied in the direction of active ingredients of heterocyclic compounds, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problem of cefazolin sodium pentahydrate and sulbactam sodium that are not disclosed in any literature. Problems such as combination application of tannin and sodium

Inactive Publication Date: 2012-12-12
SHENZHEN CHINA RESOURCES GOSUN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] At present, there is no document in this field to disclose the combined application of cefazolin sodium pentahydrate and sulbactam sodium

Method used

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  • Composition of cefazolin sodium pentahydrate and sulbactam sodium
  • Composition of cefazolin sodium pentahydrate and sulbactam sodium
  • Composition of cefazolin sodium pentahydrate and sulbactam sodium

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Experimental program
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Effect test

Embodiment 1

[0021] 1. Experimental drug

[0022] Cefazolin Sodium Pentahydrate: batch number: 20090601, potency: 93.4%, product of Shenzhen Jiuxin Pharmaceutical Co., Ltd.;

[0023] Cefazolin sodium: batch number: 090415, potency: 92.7%, commercially available product;

[0024] Sulbactam sodium: batch number: 0409-9706, potency: 86.2%, standard product of China Institute for the Control of Pharmaceutical and Biological Products;

[0025] Cefazolin sodium pentahydrate / sulbactam sodium (1:1, 2:1, 4:1, 8:1);

[0026] Cefazolin sodium / sulbactam sodium (1:1, 2:1, 4:1, 8:1);

[0027] 2. Test strains

[0028] 2.1 Standard strains: Escherichia coli ATCC25922, ATCC700603, Staphylococcus aureus ATCC29213, Streptococcus pneumoniae ATCC49619.

[0029] 2.2 93 strains of Gram-negative bacteria were tested for enzyme production by nitrocefin:

[0030] Escherichia coli (37 strains)

[0031] Enzyme-producing Escherichia coli (27 strains,)

[0032] Non-enzyme-producing Escherichia coli (10 strains) ...

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Abstract

The invention relates to a composition of cefazolin sodium pentahydrate and sulbactam sodium. Compared with the antibacterial effect of cefazolin sodium pentahydrate cefazolin sodium, the composition has excellent antibiotic activity and low resistant rates.

Description

technical field [0001] The invention relates to a composition of cefazolin sodium pentahydrate and sulbactam sodium. Background technique [0002] Cefazolin sodium pentahydrate is based on α-type cefazolin sodium, and its finer structure has been discovered. In the microstructure, a single crystal formed by two molecules of cefazolin, ten sub-water and one sodium ion Chelating structure. Cefazolin and sodium ions are combined by coordination bonds and covalent bonds. In the crystalline state, two Cefazolin molecules are arranged to form a tunnel-like cavity, and water molecules and sodium ions exist in the cavity. Azoline together forms a chelated macromolecular structure and is a stable chelated crystal. [0003] The chemical name of cefazolin sodium pentahydrate is: (6R, 7R)-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)sulfur]methyl]-7-[ (1H-tetrazol-1-yl)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt pentahydrate. Its structural formula is a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/546A61K31/43A61P31/04
Inventor 黄权华杨战鏖秋晖戴丽君
Owner SHENZHEN CHINA RESOURCES GOSUN PHARMA CO LTD
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