Method for uploading cefazolin sodium medicine film on micro-arc oxidation titanium implant

A cefazolin sodium, micro-arc oxidation technology, applied in prosthesis, medical science, coating and other directions, can solve the problems of poor biological activity, low binding strength, long healing time, etc., to improve binding ability and improve biological activity , Improve the effect of surface biological activity

Inactive Publication Date: 2012-07-04
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are generally problems such as poor biological activity, low binding strength, and long healing time when it is implanted into the human body.

Method used

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  • Method for uploading cefazolin sodium medicine film on micro-arc oxidation titanium implant
  • Method for uploading cefazolin sodium medicine film on micro-arc oxidation titanium implant
  • Method for uploading cefazolin sodium medicine film on micro-arc oxidation titanium implant

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Experimental program
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Effect test

specific Embodiment approach 1

[0018] Specific embodiment one: the method for loading cefazolin sodium drug film on the micro-arc oxidation titanium implant of the present embodiment comprises the following four steps:

[0019] Step 1: Do micro-arc oxidation. Place the titanium implant in a stainless steel tank containing an alkaline electrolyte, use the titanium implant as the anode, and the stainless steel tank as the cathode; during the oxidation process, the temperature of the tank is controlled by the cooling system figure 1 and figure 2 ), the thickness of the micro-arc oxidation coating is 3-10 microns.

[0020] Step 2: cefazolin sodium injection is dissolved in deionized water, and a certain concentration of cefazolin sodium aqueous solution is prepared.

[0021] Step 3: immerse the micro-arc oxidized titanium substrate in an aqueous solution of cefazolin sodium for a certain period of time.

[0022] Step 4: Take out the micro-arc oxidation titanium substrate soaked in cefazolin sodium, put it in ...

specific Embodiment approach 2

[0030] Embodiment 2: This embodiment is different from Embodiment 1 in that the energy in the oxidation process is provided by an adjustable high-voltage and high-frequency bipolar pulse power supply. The pulse parameters are voltage 200-500V, frequency 400-800Hz, duty cycle 4~10%. Other steps are the same as in the first embodiment. When the applied voltage exceeds the critical voltage of the insulating film on the titanium surface placed in the electrolyte, the spark discharge generated on the surface of the part will oxidize the matrix and form dense TiO 2 Oxide coating, by controlling the composition of the electrolyte, trace elements that are beneficial to the living body can be introduced into the surface of the oxide layer through the oxidation process of the material, and then the sample treated by micro-arc oxidation is immersed in a certain concentration of cefazolin sodium In the aqueous solution, the soaked sample is subsequently taken out, heated and dried to obt...

specific Embodiment approach 3

[0031] Embodiment 3: The difference between this embodiment and Embodiment 1 is that the energy of the micro-arc oxidation process is provided by an adjustable high-voltage and high-frequency bipolar pulse power supply, the pulse voltage is 200-500V, the frequency is 400-800Hz, The duty ratio is 4-20%, and the solution temperature is 0-50°C. Within the above selected electrical parameters of the micro-arc oxidation, the thickness of the coating can reach 3-10 microns after micro-arc oxidation for 5 minutes. Other steps are the same as in the first embodiment.

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Abstract

A method for uploading a cefazolin sodium medicine film on a micro-arc oxidation titanium implant relates to a method for applying an antibiotic medicine film on a medical titanium metal modified coating which serves as a bone substitute. The biological activity of the titanium implant after micro-arc oxidation treatment is greatly improved; and the antibiotic can prevent the wound infection caused by implanting the implant into a body and improve the healing capability of a wound. The method comprises the following steps: putting the titanium implant into a stainless steel tank with alkaline electrolyte; through controlling electrical parameters of the micro-arc oxidation, forming a layer of micro-arc oxidation coating on the titanium surface through breakdown discharge on the titanium surface by using a bipolar pulse power; dipping a titanium substrate after the micro-arc oxidation into an aqueous solution of cefazolin sodium; taking out the micro-arc oxidation titanium substrate soaked in the cefazolin sodium; and putting the titanium substrate into a drying chamber, and drying to obtain micro-arc oxidation titanium implant uploaded with the cefazolin sodium medicine film. By the method, the wound infection caused by implanting the implant into the body can be prevented and the healing of the wound can be promoted.

Description

technical field [0001] The invention relates to a method for coating an antibiotic drug film on a medical titanium metal modified coating as a bone substitute. Background technique [0002] As important biomedical materials, titanium and titanium alloy materials have high mechanical strength, high toughness and excellent fatigue resistance, and are widely used in the replacement of hard tissues such as joints, teeth, and bones in the human body. However, there are generally problems such as poor biological activity, low binding strength, and long healing time when implanted into the human body. In order to improve the bioactivity of medical titanium metal and promote its combination with human bone tissue, a common method is to ceramicize or coat the surface of medical titanium metal with a bioactive coating. The preparation of titanium dioxide by micro-arc oxidation on titanium surface is a hot spot in the research on the surface modification of medical titanium metal in r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/28A61L27/54C25D11/26
Inventor 魏大庆成夙周玉
Owner HARBIN INST OF TECH
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