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Method for coating micro-arc oxidation titanium implant with cefazolin sodium and chitosan composite drug membrane

A cefazolin sodium, micro-arc oxidation technology, applied in prosthesis, medical science, coating and other directions, can solve the problem of lack of anti-inflammatory effect, and achieve the prevention of wound infection, good sustained release effect, and accelerated wound healing. Effect

Inactive Publication Date: 2012-07-11
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, when the bone substitute is implanted in the body, bacteria and viruses may be brought into the body to cause wound infection. Loading antibiotics on the surface of the bone substitute can prevent wound infection and promote rapid wound healing. After contact with blood, it will be released quickly, and it will not have anti-inflammatory effect

Method used

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  • Method for coating micro-arc oxidation titanium implant with cefazolin sodium and chitosan composite drug membrane
  • Method for coating micro-arc oxidation titanium implant with cefazolin sodium and chitosan composite drug membrane
  • Method for coating micro-arc oxidation titanium implant with cefazolin sodium and chitosan composite drug membrane

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specific Embodiment approach 1

[0019] Specific embodiment one: the method for loading cefazolin sodium and chitosan composite drug film on the micro-arc oxidation titanium implant of the present embodiment includes the following four steps:

[0020] Step 1: Do micro-arc oxidation. Place the titanium implant in a stainless steel tank containing an alkaline electrolyte, use the titanium implant as the anode, and the stainless steel tank as the cathode; during the oxidation process, the temperature of the tank is controlled by the cooling system figure 1 and figure 2 ).

[0021] Step 2: cefazolin sodium injection is dissolved in deionized water, and a certain concentration of cefazolin sodium aqueous solution is prepared.

[0022] Step 3: Chitosan with a deacylation rate of more than 90% is added to the mixed solution of acetic acid and deionized water, and stirred until the chitosan is completely dissolved.

[0023] Step 4: drop the prepared cefazolin sodium aqueous solution into the chitosan aqueous soluti...

specific Embodiment approach 2

[0036] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the energy of the micro-arc oxidation process is provided by an adjustable high-voltage and high-frequency bipolar pulse power supply, the pulse voltage is 200-500V, the frequency is 400-800Hz, The duty ratio is 4-20%, and the solution temperature is 0-50°C. Within the above selected electrical parameters of the micro-arc oxidation, the thickness of the coating can reach 3-10 microns after micro-arc oxidation for 5 minutes. Other steps are the same as in the first embodiment.

specific Embodiment approach 3

[0037] Specific embodiment three: the method for loading cefazolin sodium drug film on the micro-arc oxidation titanium implant of the present embodiment includes the following six steps:

[0038] Step 1: Micro-arc oxidation: Put pure Ti in a solution containing EDTA-2Na, NaOH, Na 2 SiO 3 9H 2 O and Ca(CH3COO) 2 ·H 2 O (concentrations are set at 15 g / L, 20 g / L, 14.2 g / L and 8.8 g / L respectively) in a stainless steel tank made of deionized water as a solvent, the voltage of the power supply is 400V, The void ratio was 8%, the frequency was 600 Hz, and the oxidation time was 5 min, so that a micro-arc oxidation coating was formed on the surface of the pure titanium implant with a thickness of 5 microns.

[0039] EDS energy spectrum detection is carried out on the coating treated by the present invention, and there are trace active elements of Na, Si and Ca in the coating.

[0040] Step 2: Dissolve the cefazolin sodium injection in deionized water to prepare an aqueous solut...

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Abstract

A method for coating micro-arc oxidation titanium implant with cefazolin sodium and chitosan composite drug membrane relates to coating an antibiotic drug membrane having sustained release and degradation actions to a titanium implant surface. According to the method for coating micro-arc oxidation titanium implant with cefazolin sodium and chitosan composite drug membrane, the biological activity of the titanium implant subjected to micro-arc oxidation is greatly improved, the antibiotic drug membrane can avoid causing wound infection when the implant is implanted into a body, and the healing ability is improved. The method includes placing titanium implant in a stainless steel groove containing an alkaline electrolyte, using a bipolar impulsing power source, controlling micro-arc oxidation electrical parameters, enabling the titanium surface to form a micro-arc oxidation coating by a disruptive discharge of the titanium surface; immersing titanium matrix after micro-arc oxidation into a blended solution of cefazolin sodium and chitosan for soaking; taking out the micro-arc oxidation titanium implant which is subjected to sufficient immersion, and drying the implant in a drying box. The method for coating micro-arc oxidation titanium implant with cefazolin sodium and chitosan composite drug membrane is simple in operation, low in cost and good for environment, and can introduce non-toxic substances into the micro-arc oxidation coating and the composite drug membrane.

Description

technical field [0001] The invention relates to a method for coating the surface of a titanium implant with a slow-release and degradable antibiotic drug film. Background technique [0002] The preparation of titanium dioxide by micro-arc oxidation on titanium surface is a hot spot in the research on the surface modification of medical titanium metal in recent years. The titanium dioxide coating prepared by this method contains a micron-sized porous structure, and calcium, phosphorus, silicon and strontium can be introduced into the coating. Many studies have proved that micro-arc oxidation-treated titanium metal is an ideal bone substitute. However, when the bone substitute is implanted into the body, bacteria and viruses may be brought into the body to cause wound infection. Loading antibiotics on the surface of the bone substitute can prevent wound infection and promote rapid wound healing. After contact with blood, it will be released quickly, and it will not have anti-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C25D11/26A61L27/06A61L27/28A61L27/54
Inventor 魏大庆成夙周玉
Owner HARBIN INST OF TECH
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