Method for purifying cefazolin acid

Abstract

The invention discloses a method for purifying a cefazolin acid, which is implemented by preparing a crude cefazolin acid product with a content of less than 97% into a sodium salt firstly; then, carrying out adsorption on the sodium salt by using a macroporous resin so as to remove impurities; and finally, reducing the sodium salt to an acid, so that the content, individual impurity and color grade of the obtained cefazolin acid satisfy the demands of being directly used for preparing cefazolin sodium by using a freeze-drying method; and the cefazolin acid can be directly used. The method disclosed by the invention overcomes the defects that single purification in existing purification methods can not meet the requirements of use.

Description

technical field

[0001] The invention belongs to the technical field of preparation of cephalosporin antibiotics in the pharmaceutical and chemical industry, and in particular relates to a method for purifying cefazolin acid. Background technique

[0002] Cefazolin sodium, also known as cephalosporin Ⅴ, Pioneer 5, etc., is a semi-synthetic first-generation cephalosporin, which has a strong effect on gram-positive bacteria and has a strong effect on gram-negative bacteria, especially Gram-negative bacteria. The role of Lebei pneumoniae is also strong. Cefazolin acid has obvious advantages over the first-generation cephalosporins. It has enzyme resistance, high efficiency and low toxicity, and has a wide range of clinical indications. Abscess, endocarditis, sepsis, ear and soft tissue infection, etc., the treatment effect is better.

[0003] Cefazolin sodium for clinical use is injection powder, which is usually prepared by freeze-drying method, and is directly freeze-dried i...