The invention discloses a process for cleaning an optical resin lens substrate and a forming mould. The process includes the steps of cleaning liquid preparation, ultrasonic cleaning, ultrasonic rinsing, drying and the like. The cleaning liquid is prepared by adding, in weight percent, 1-10% of alkyl sodium sulfonate, 1-5% of TX-10 and 1-5% of citric acid into sodium hydroxide with the concentration of 1-10% after mixing, neutralizing the mixture to reach the pH (potential of hydrogen) value ranging from 7 to 7.5, and adding water to reach 100%. The cleaning liquid is high in cleaning strength, dirt such as resin, adhesive, fingerprint, grinding residue and the like adhered to the surface of the resin lens substrate or the forming mould can be rapidly removed, the surface of the substrate or the forming mould is not damaged, water solution in the cleaning liquid can be reused, and the cleaning liquid is fine in economical efficiency, safe in use, simple in discharge, environment-friendly, non-corrosive, non-volatile, non-hazardous and non-combustible.