The invention discloses a self-heating moxibustion stick which comprises self-heating materials and a seal package. The seal package comprises a body, a seal layer and an adhesive sticker, air holes are formed in the stick body, and each of the air holes is covered with an air-tight seal film; in addition, the invention further discloses a bubble cap air hole forming device and a production line of the self-heating moxibustion stick, and the device comprises a frame, and a bubble cap forming device, an air hole forming device, a basement membrane stick device, a padding device, a first heat-seal device, an unguent adding device, a second heat-seal device and a die cutting device which are arranged on the frame and connected successively. The self-heating moxibustion stick is small in size, long in heating time, high in heating speed, stable in temperature, and convenient to carry and use. The bubble cap air hole forming device is simple in structure, high in reliability, and suitable for production line operations; the production line of the self-heating moxibustion stick is of an industrial assembly line large-scale production system, and is easy and reasonable in structure, and high in reliability and production efficiency.