The invention belongs to the technical field of medicine and relates to clopidogrel and salt submicron emulsion injection thereof as well as a preparation method of the clopidogrel and the salt submicron emulsion injection thereof. Particularly, the invention provides clopidogrel, salt submicron emulsion injection including clopidogrel, salt, oil for injection, assistant emulsifier, isoosmotic adjusting agents, pH adjusting agents and water for injection, and a preparation method of the clopidogrel and the salt submicron emulsion injection. 100 mL of the injection comprises clopidogrel, 0.05 g to 0.15 g salt (measured according to clopidogrel), 5 g to 30 g of oil for injection, 0.5 g to 3.4 g of emulsifier, 0 g to 1 g of assistant emulsifier, 2.0 g to 4.0 g of isoosmotic adjusting agents, and 7.0 g to 9.0 g of pH adjusting agents, and 100 mL of water for injection is added. The clopidogrel and the salt submicron emulsion injection thereof, provided by the invention, have the physical chemical property conforming to the requirement of drug for intravenous use and are suitable for clinical application.