Lonicera hypoglauca Miq stem-leaf extract, its medicine use and medicine composition

A technology of Lonicera red glandular extract, which is applied to the extract of effective parts of Lonicera red glandularia. From the field of stem and leaf extracts of Lonicera red glandularis, it can solve the problem of no red glandular honeysuckle, and achieve no harmful solvents, Reduce production cost, strong effect on liver damage

Inactive Publication Date: 2008-06-04
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, there has been no report on other effective parts of Lonicera red glandularis

Method used

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  • Lonicera hypoglauca Miq stem-leaf extract, its medicine use and medicine composition
  • Lonicera hypoglauca Miq stem-leaf extract, its medicine use and medicine composition
  • Lonicera hypoglauca Miq stem-leaf extract, its medicine use and medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Take 20g of the stem and leaf of Lonicera red glandularis, extract with petroleum ether under reflux at 80°C for 4 hours to degrease, then extract 12 times the volume of the medicinal material with 60% ethanol, heat under reflux at 85°C for three times, 1 hour each time. The extracts were combined, and the solvent was recovered under reduced pressure. The obtained concentrated solution was segmented by D101 macroporous resin, firstly eluted with water to remove impurities, and then eluted with 10% and 25% ethanol in sequence. Combine the 10% and 25% alcohol eluents, concentrate, centrifuge to remove the precipitate, take the supernatant, extract 4 times with water-saturated n-butanol, combine the extracts, concentrate and dry in vacuo to obtain the product. The ratio of the content of dwarf glycosides is 1:6.5, and the content of total iridoid glycosides is 60.58%.

Embodiment 2

[0051] Take 20g of the stem and leaf of Lonicera red glandularis, extract with petroleum ether under reflux at 80°C for 4 hours for degreasing, then extract with 10 times the volume of 80% ethanol under reflux at 85°C for three times, 1 hour each time. The extracts were combined, and the solvent was recovered under reduced pressure. The resulting concentrated solution was segmented through HPD100 macroporous resin, firstly eluted with water to remove impurities, and then eluted with 30% ethanol. After the ethanol eluate is concentrated, the precipitate is removed by centrifugation, the supernatant is taken, extracted 4 times with water-saturated n-butanol, the extracts are combined, concentrated and vacuum-dried to obtain the product. The content ratio of swertigin and loganin is 1: 6.6, the total iridoid glycoside content was 59.34%.

Embodiment 3

[0053] Take 20g of the stem and leaf of Lonicera red glandularis, extract with petroleum ether at 80°C for 2 hours under reflux for degreasing, then extract with 8 times the volume of 60% ethanol by reflux at 85°C twice for 1 hour each time. The extracts were combined, and the solvent was recovered under reduced pressure. The resulting concentrated solution was segmented through D101 macroporous resin, and firstly eluted with water, and then eluted with 10% and 25% ethanol in sequence. The ethanol eluents were combined and concentrated, centrifuged to remove the precipitate, the supernatant was taken, extracted 4 times with water-saturated n-butanol, the extracts were combined, concentrated and vacuum-dried to obtain the product. The content ratio of swertigin and loganin was 1 : 4.7, the total iridoid glycoside content is 60.22%.

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Abstract

The present invention relates to lonicera hypoglauca miq effective region extract, namely, stem and leaf extract of lonicera hypoglauca miq. Its preparation method includes the following steps: using lonicera hypoglauca miq, stem and leaf as raw material, degreasing by using low-polarity organic solvent, using ethyl alcohol to make extraction to obtain ethyl alcohol extract, concentrating, feeding the concentrate into macroporous resin column, using water to make elution, then using ethyl alcohol to make elution, collecting ethyl alcohol eluent, concentrating eluent, centrifugalization to remove precipitate, taking out supernatant fluid, using n-butyl alcohol to make extraction, concentrating extract and drying so as to obtain the invented product with high activity for protecting liver.

Description

technical field [0001] The invention relates to the field of natural medicines, in particular to an extract from effective parts of Lonicera hypoglauca Miq, that is, an extract from stems and leaves of Lonicera hypoglauca Miq, which has strong hepatoprotective activity. Background technique [0002] Red gland honeysuckle, Latin scientific name: Lonicera hypoglauca Miq, English name: Honeysuckle, is an evergreen twining shrub, up to 8 meters long, the stem is often hollow; there are many branches, and the tender part is puberulent. Leaves opposite, papery, ovate to ovate-oblong, 4-11 cm long, 1.5-5 cm wide, apex shortly pointed to acuminate, base round or nearly cordate, upper part nearly glabrous, lower part covered with flesh Hairy, densely covered with purple-red or brown-red glandular points, petiole about 5-8 mm long. Flowers open in early summer, white, then turn yellow. The flower buds are 2.5 to 4.5 cm long. Hairless or sparsely coated, lower lip inverted in open c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/355A61K9/48A61K9/20A61K9/08A61K9/16A61P1/16A61K127/00A61K135/00
Inventor 李萍贺清辉李会军毕志明
Owner CHINA PHARM UNIV
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