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External applied preparation for etodolac

A technology of etodolac and ointment, applied in the field of new pharmaceutical preparations

Active Publication Date: 2009-12-23
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no other dosage form clinically at present, and the invention patent with the patent application number 03123075.x only mentions etodolac

Method used

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  • External applied preparation for etodolac
  • External applied preparation for etodolac
  • External applied preparation for etodolac

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] etodolac common liniment

[0064] etodolac 45g

[0065] Ethanol 35ml

[0066] Propylene glycol 180ml

[0067] Add phosphate buffered saline (PBS) to 1000ml

[0068] Preparation Process:

[0069] First dissolve etodolac in the prescribed amount of ethanol and propylene glycol, and then add the prescribed amount of phosphate buffer saline (PBS).

Embodiment 2

[0071] etodolac common liniment

[0072] etodolac 45g

[0073] Ethanol 200ml

[0074] Propylene glycol 500ml

[0075] Add distilled water to 1000ml

[0076] Preparation Process:

[0077] First dissolve etodolac in the prescribed amount of ethanol and propylene glycol, and then add distilled water to 1000ml. The preparation described in this method can also be made into a liniment in a specific container.

Embodiment 3

[0079] etodolac ointment

[0080] etodolac 45g

[0081] Capomer 940 20

[0082] Hypromellose 40g

[0083] Glycerin 400g

[0084] Ethylparaben 2g

[0085] Add distilled water to 1000ml

[0086] Preparation Process:

[0087] Disperse hydroxypropyl methylcellulose in hot water at about 80°C, cool it to form a clear solution, and disperse Carbomer 940 in water and mix it with glycerin, mix the above solution, and then add the dissolved prescription amount Put the hot distilled water of etodolac until it swells into a gel, then add an aqueous solution containing ethylparaben, and add water to a sufficient amount to obtain etodolac ointment.

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PUM

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Abstract

Osteoarthritis and rheumatoid arthritis are common chronic diseases with high incidence and difficult to cure in our country, requiring long-term medication. At present, non-steroidal anti-inflammatory drugs (NSAIDs) are the most important drugs for the treatment of arthritis, but most of them are oral preparations, which have serious adverse reactions. Etodolac belongs to indole non-steroidal anti-inflammatory analgesics and plays an important role in the treatment of arthritis, but the current oral dosage forms have many systemic adverse reactions, which bring difficulties to patients with long-term medication. Therefore, according to patients Need, the present invention develops etodolac external preparation, which can not only greatly reduce the adverse reactions of the drug, but also is especially suitable for the long-term drug treatment of arthritis.

Description

Technical field [0001] The invention belongs to new pharmaceutical preparations. Background technique [0002] Arthritis is a common chronic disease, the most common of which are osteoarthritis and rheumatoid arthritis. It is estimated that there are more than 100 million arthritis patients in my country, and the number is still increasing. According to statistics, half of the people over the age of 50 in my country suffer from osteoarthritis; 90% of the women and 80% of the men over the age of 65 suffer from osteoarthritis. The prevalence of rheumatoid arthritis in my country is 0.34% to 0.36%. According to reports, the life expectancy of patients with severe rheumatoid arthritis is shortened by about 10 to 15 years. Arthritis is not a disease of old age and can affect people of all ages, including children. [0003] (1) Osteoarthritis (OA) is a chronic joint disease characterized by degeneration and destruction of articular cartilage and bone hyperplasia. Osteoarthritis...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K9/06A61K9/107A61K9/12A61K31/407A61P19/02A61P29/00
Inventor 赵志全
Owner LUNAN PHARMA GROUP CORPORATION
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