Asthma treating hydrogel plaster prepn and its preparing process

A hydrogel patch, a technology for asthma, which is applied in the field of traditional Chinese medicine preparations for the treatment of asthma, can solve the problems of uneven curative effect, rough dosage form, low water content of the patch, and achieves a reasonable and simple extraction process, good application compliance, and good administration. Accurate dose of medicine

Inactive Publication Date: 2007-08-22
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The above-mentioned three kinds of patches with white mustard seed, corydalis, asarum, kansui, ephedra, and scutellaria baicalensis as main ingredients have the advantages of accurate dosage, convenient use, and can be peeled off at any time, which overcomes the traditional white mustard seed externally applied dosage form. Rough, different composition, and inconsistent curative effect, but these kinds of patches have low water content, low viscosity, and easy to fall off

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0047] 1. Take 10 grams of Corydalis Corydalis, 10 grams of Herba Asarum, 10 grams of White Mustard Seed, 5 grams of Gansui, 5 grams of Scutellaria Baicalensis, and 5 grams of Ephedra, and use 75% ethanol for ultrasonic extraction for 30 minutes, and recover the ethanol under reduced pressure until there is no alcohol smell, and the original Herbal extracts. Take 10 grams of fresh ginger, wash, slice, squeeze the juice, and collect the ginger juice.

[0048] 2. Take 60 grams of deionized water, 0.001 grams of disodium edetate, 0.01 grams of Tween 80, mix well, stir at 800r / min, add 1g of Carbomer-940 resin, stir at 1800r / min, and divide into 3 batches Add 20 grams of resin Carbomer-941, stir at 800r / min for 2 hours until uniform, pour into a kneader, adjust the temperature to 50°C, stir for 2 hours, vacuumize, stir evenly, and let stand to obtain a blank matrix.

[0049] 3. Stir the blank matrix at 800r / min, and slowly add 10% NaOH to make the pH value 5, and slowly add 22.67...

example 2

[0052] 1. Take 5 grams of Corydalis Corydalis, 5 grams of Asarum, 5 grams of White Mustard Seed, 10 grams of Gansui, 10 grams of Scutellaria Baicalensis, and 10 grams of Ephedra, and use 75% ethanol for ultrasonic extraction for 30 minutes, and recover the ethanol under reduced pressure until there is no alcohol smell, and the original Herbal extracts. Take 10 grams of fresh ginger, wash, slice, squeeze the juice, and collect the ginger juice.

[0053] 2. Take 60 grams of deionized water, 0.001 grams of disodium edetate, 0.01 grams of Tween 80, mix well, stir at 800r / min, add 1g of Carbomer-940 resin, stir at 1800r / min, and divide into 3 batches Add 20 grams of resin Carbomer-941, stir at 800r / min for 2 hours until uniform, pour into a kneader, adjust the temperature to 50°C, stir for 2 hours, vacuumize, stir evenly, and let stand to obtain a blank matrix.

[0054] 3. Stir the blank matrix at 800r / min, and slowly add 10% NaOH to make the pH value 5, and slowly add 22.67% of t...

example 3

[0057] 1. Take 8 grams of Corydalis Corydalis, 8 grams of Herba Asarum, 8 grams of White Mustard Seed, 6 grams of Kansui, 6 grams of Scutellaria, and 6 grams of Ephedra, and use 75% ethanol for ultrasonic extraction for 30 minutes, and recover the ethanol under reduced pressure so that there is no alcohol smell, and the original Herbal extracts. Take 10 grams of fresh ginger, wash, slice, squeeze the juice, and collect the ginger juice.

[0058] 2. Take 60 grams of deionized water, 0.001 grams of disodium edetate, 0.01 grams of Tween 80, mix well, stir at 800r / min, add 1g of Carbomer-940 resin, stir at 1800r / min, and divide into 3 batches Add 20 grams of resin Carbomer-941, stir at 800r / min for 2 hours until uniform, pour into a kneader, adjust the temperature to 50°C, stir for 2 hours, vacuumize, stir evenly, and let stand to obtain a blank matrix.

[0059] 3. Stir the blank matrix at 800r / min, and slowly add 10% NaOH to make the pH value 5, and slowly add 22.67% of the tota...

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PUM

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Abstract

The asthma treating hydrogel plaster preparation consists of one lining layer of non-woven fabric and one medicine containing matrix layer comprising active medicine and blank matrix in the weight ratio of 1-3. The active medicine is prepared with corydalis tuber 5-10 weight portions, asarum herb 5-10 weight portions, white mustard seed 5-10 weight portions, kansui root 5-10 weight portions, skullcap root 5- 10 weight portions and ephedra 5-10 weight portions through alcohol and ultrasonic extraction and ginger 10-20 weight portions through squeezing to obtain juice. The blank matrix is prepared with deionized water 60- 80 weight portions, carbomer-940 resin 1-3 weight portions, carbomer-941 resin 10-20 weight portions, Tween-80 0.01-0.03 weight portions, EDTA-2-Na 0.001-0.004 weight portions and alcohol solution (95 %) 1-3 weight portions. The plaster can treat asthma effectively.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine preparation for treating asthma. Background technique [0002] Asthma is a common intractable respiratory disease in clinical practice. It occurs mostly in children and people over 50 years old. In particular, chronic airway inflammation involving mast cells, eosinophils, and T lymphocytes and other diseases characterized by airway hyperresponsiveness (BHR). Bronchial asthma is the most common clinical respiratory disease. According to foreign reports such as Europe and the United States, the incidence rate of asthma is about 0.3% to 9.2%, with great regional differences, and the incidence rate of asthma in some areas is as high as 30%. According to relevant domestic reports, the incidence rate of asthma is about 1%, and children can reach 3%. %. The difference in the incidence rate in various regions is related to various factors such ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/00A61K9/70A61K47/34A61P11/06A61K47/32
Inventor 刘强穆晓敏
Owner SOUTHERN MEDICAL UNIVERSITY
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