Antigenic composite, multi-clone antibody prepared by it and its application

A polyclonal antibody and composition technology, applied in the direction of antibodies, drug combinations, allergic diseases, etc., can solve problems such as side effects, abnormal induction and regulation, and non-specific killing and clearing effects
CN101088560AInactive Publication Date: 2007-12-19徐何 +2
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
徐何
Publication Date
2007-12-19
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to antigen composition comprising leukocyte and cell line mixture. The antigen composition may be animal immunized to obtain new generation of polyclonal antibody possessing specific abnormal immunity reaction preventing and treating effect. The present invention proposes immunotherapy on abnormal immunity reactions, including autoimmune diseases, implant-anti-host diseases, rejection reaction, etc. The polyclonal antibody the present invention provides acts directly on lymphocyte and monocyte to be determined to participate in the abnormal immunity reaction while having less removal and blocking on static or unactivated lymphocyte.
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Description

technical field

[0001] The invention relates to a composition used as an antigen to immunize animals, and the use of the antigen composition to prepare a new generation of polyclonal antibodies and the use of the polyclonal antibodies in treating and preventing abnormal immune reactions. The present invention also proposes immunotherapy for abnormal immune responses, including autoimmune diseases, graft-versus-host disease, allogeneic organ, tissue, cell transplantation rejection, heterogeneous allogeneic organ, Rejection after tissue and cell transplantation, multiple sclerosis, diabetes, etc. technical background

[0002] The French biologist Bert conducted a comparative and systematic study on allografts for the first time in his 1864 study (Bert P.J Anat.Physiol 1864, 1:85). The first relatively clear affirmation that lymphocytes play a dominant role in rejection was proposed by Billingham et al. (Billingham R, et al. N.Y. Acad. Sci 1960, 87: 457) and Anderson et al. a...

Claims

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