Antigenic composite, multi-clone antibody prepared by it and its application

A polyclonal antibody and composition technology, applied in the direction of antibodies, drug combinations, allergic diseases, etc., can solve problems such as side effects, abnormal induction and regulation, and non-specific killing and clearing effects

Inactive Publication Date: 2007-12-19
徐何 +2
View PDF7 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The acquisition of these preparations still belongs to the old generation of polyclonal antibodies due to the use of thymocyte antigens, and these polyclonal antibody preparations are not specific to white blood cells participating in the immune reaction, but due to normal white blood cells, bystander cells

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Antigenic composite, multi-clone antibody prepared by it and its application
  • Antigenic composite, multi-clone antibody prepared by it and its application
  • Antigenic composite, multi-clone antibody prepared by it and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0021] Definition of Terms

[0022]"Immunoglobulin" or "Ig": defined herein as a group of plasma globulin proteins that function as antibodies. Immunoglobulins include IgA, IgG, IgM, IgE, or IgD and / or subtypes thereof, such as IgG 1 , IgG 2 , IgG 3 , IgG 4 , IgA 1 , or IgA 2 . IgA functions as an essential antibody and is present in body secretions such as tears, human milk, gastrointestinal secretions, and mucus in the respiratory and genitourinary tracts. IgG functions as the most common circulating antibody.

[0023] "Polyclonal antibody": A mixture of different antibody molecules that bind and react with more than one immunogenic determinant of an antigen. The term "polyclonal antibody" in the present invention includes polyclonal antibodies isolated and purified from blood, secretions or other body fluids such as peritoneal fluid and from egg cells of mammals.

[0024] "An isolated or purified polyclonal antibody": refers to a polyclonal antibody isolated and pu...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Molecular weightaaaaaaaaaa
Login to view more

Abstract

The present invention relates to antigen composition comprising leukocyte and cell line mixture. The antigen composition may be animal immunized to obtain new generation of polyclonal antibody possessing specific abnormal immunity reaction preventing and treating effect. The present invention proposes immunotherapy on abnormal immunity reactions, including autoimmune diseases, implant-anti-host diseases, rejection reaction, etc. The polyclonal antibody the present invention provides acts directly on lymphocyte and monocyte to be determined to participate in the abnormal immunity reaction while having less removal and blocking on static or unactivated lymphocyte.

Description

technical field [0001] The invention relates to a composition used as an antigen to immunize animals, and the use of the antigen composition to prepare a new generation of polyclonal antibodies and the use of the polyclonal antibodies in treating and preventing abnormal immune reactions. The present invention also proposes immunotherapy for abnormal immune responses, including autoimmune diseases, graft-versus-host disease, allogeneic organ, tissue, cell transplantation rejection, heterogeneous allogeneic organ, Rejection after tissue and cell transplantation, multiple sclerosis, diabetes, etc. technical background [0002] The French biologist Bert conducted a comparative and systematic study on allografts for the first time in his 1864 study (Bert P.J Anat.Physiol 1864, 1:85). The first relatively clear affirmation that lymphocytes play a dominant role in rejection was proposed by Billingham et al. (Billingham R, et al. N.Y. Acad. Sci 1960, 87: 457) and Anderson et al. a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K39/395A61P37/02
Inventor 徐何于锋刘子栋
Owner 徐何
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap