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Methylergometrine Maleate powder injection and preparation method thereof

A technology of methysergide maleate and maleic acid, which is applied in powder delivery, freeze-drying delivery, diseases, etc., can solve problems such as poor stability of aqueous injections, drug decomposition and destruction, light and heat instability, etc., and achieve Effects of reducing irritation and increasing compliance

Inactive Publication Date: 2008-02-20
韩志强
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Methergonovine maleate is relatively unstable to light and heat, and it needs to be heated and sterilized when preparing its aqueous injection, so it is easy to cause drug decomposition and damage, and the aqueous injection has poor stability, so it needs to be kept away from light and low temperature
All of these have affected the safe and effective use of the drug in clinical practice.

Method used

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  • Methylergometrine Maleate powder injection and preparation method thereof

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Embodiment Construction

[0017] The following examples and experimental data of influencing factors are used to further illustrate the technical solution of the present invention, but not to limit the technical characteristics of the present invention.

[0018] The specific process and steps of preparing the freeze-dried powder injection of the present invention are as follows:

[0019] (1) Dosing

[0020] Preparation: all kinds of liquid preparation supplies are ready;

[0021] Dissolving excipients: weigh the prescribed amount of pharmaceutically acceptable carrier, add appropriate amount of sterilized water for injection, dissolve at room temperature, add appropriate amount of activated carbon for needles, stir at room temperature for 30 minutes, and coarsely filter;

[0022] Dissolving the main drug: take the prescribed amount of methysergide maleate, add appropriate amount of water to dissolve, add to the above crude filtrate, add water to the full amount of the prescription;

[0023] Steriliza...

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Abstract

The present invention relates to a methylergometrine maleate powder injection, which pertains to the field of pharmaceutical preparations; the present invention contains the methylergometrine maleate which is taken as the active ingredient and the pharmaceutically acceptable carriers, wherein, the weight ratio of the methylergometrine maleate and the pharmaceutically acceptable carriers is 1: 15 to 1: 300, the pharmaceutically acceptable carriers are one or more of the lactose, glucose, mannitol, low molecular weight dextran, sodium chloride and aminoacetic acid. The present invention also provides a preparation method of methylergometrine maleate powder injection. The powder injection of the present invention has good stability, easy storage and transportation, furthermore, the irritation is significantly decreased and the compliance of the patients is increased.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a metergide maleate powder injection and a preparation method thereof. Background technique [0002] Methylergonovine Maleate is a uterotonic drug with the molecular formula: C 20 h 25 N 3 o 2 ·C 4 h 4 o 4 , the structural formula is: [0003] [0004] Clinically, it is mainly used for uterine bleeding caused by weak uterine contraction or poor recovery after childbirth or abortion. At present, the drug has not been produced and marketed in China, and the dosage forms marketed abroad are tablets and aqueous injections. The aqueous injection is 1ml of an aqueous solution containing 0.2mg of metergonovine maleate. Methergonovine maleate is relatively unstable to light and heat, and needs to be heated and sterilized when preparing its aqueous injection, so it is easy to cause drug decomposition and damage, and the aqueous injection has poor stability, so it nee...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K9/19A61K31/437A61P15/04
Inventor 韩志强贾晓冬曾杏雪田英张俊伟
Owner 韩志强
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