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Method for producing male contraceptive raw material medicine-gossypol acetate

A technology of gossypol acetate and production method, which is applied in the separation/purification of carbonyl compounds, organic chemistry, etc., can solve the problems of restricting the popularization and application of gossypol acetate, difficulty in realizing industrialized production, and unbearable production units, and achieve better separation effect Good, low equipment requirements, avoiding the effect of solvent loss

Inactive Publication Date: 2008-03-12
季萍
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Other methods use a large amount of volatile and explosive organic solvents, which are not only expensive, difficult to recycle, large waste, high cost, unaffordable to the production unit, and extremely high requirements for equipment, which brings hidden dangers to production safety and is difficult to realize industrialized production. , thus restricting the popularization and application of gossypol acetate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0022] (1) Crushing of raw materials: Sorting the cottonseed after delinting to remove mildew and rotten impurities, and then put them into a stainless steel grinder for crushing to 80 mesh, put them into a clean woven bag and tie the mouth, avoid contact with air, and prevent oxidation , not in contact with other metals except stainless steel;

[0023] (2) Stirring extraction: Soak cottonseed powder in the alcohol of 70%~90% concentration (weight) (example 70%, 80%, 90%), stir for 1~3 hours (example 1, 2, 3 hours) ; Wherein the weight ratio of cottonseed powder and the alcohol of 70%~90% concentration (weight) (example 70%, 80%, 90%) is 1: 4~6 (example 1; 4, 1: 5, 1: 6) ; Soaking temperature is 35~55 ℃ (for example 35 ℃, 45 ℃, 55 ℃).

[0024] (3) Filtration and concentration: filter the above extract with a membrane filter or a stainless steel centrifuge, add the filtrate to a stainless steel concentration tower for concentration, the vacuum degree is 0.75~0.95pa (eg 0.75, 0...

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Abstract

The present invention discloses production method of a male contraceptive raw material drug, acetic gossypol, consisting of the raw material crushing, the mixing and extraction, the filtration, the concentration, the chromatography, the secondary concentration, the repeated crystallization and so on. The present invention is of the good product quality and the convenient production.

Description

Technical field: [0001] The invention relates to a production method of a contraceptive bulk drug, which is a production method of gossypol acetate. Background technique: [0002] Gossypol acetate is a compound with a wide range of pharmacological effects, including anti-inflammation, anti-virus, anti-parasitic effects, killing tumor cells and strong anti-fertility effects. Its pharmacological effects have been recognized by the United Nations, and a large amount of use has no harm to human body or livestock, and has no residue in nature. At present, some authoritative medical research institutions in the world have found that gossypol acetate has an inhibitory effect on AIDS. [0003] As a medical raw material, gossypol acetate is generally used as a drug choice for women to fight uterine fibroids or treat endometrial odor and contraception. Since the 1960s, my country has organized research and development. At the 1996 annual meeting of inventors in California, my countr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C47/57C07C45/78
Inventor 季萍
Owner 季萍
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