2 results about "Gossypol Acetate" patented technology

The invention relates to the technical field of microbial fermentation and feed production, in particular to a free gossypol degrading bacterium YJQ-1 and application thereof.The free gossypol degrading bacterium YJQ-1 is Wickerhamomyces anomalus, is preserved in the China Center for Type Culture Collection on March 4, 2026, has the preservation number of CCTCC M 2026367 and is separated from Sichuan Dazhou sweet distiller's yeast. The strain can tolerate 2.0 g / L of gossypol acetate, and the degradation rate of 1.0 g / L of gossypol acetate within 72 h reaches 83.75%. The microbial inoculum prepared from the strain is inoculated to cottonseed meal sieved by a 40-mesh sieve according to the inoculum size of 5%, the moisture content is adjusted to 40%, solid state fermentation is performed at 30 DEG C for 7 days, the gossypol degradation rate is 86.52%, the free gossypol is only 144 mg / Kg, and nutritional indexes such as cottonseed meal crude protein and protein digestibility are remarkably improved. The technology is low-carbon and environment-friendly, the application range of the cottonseed meal is widened, and a foundation is laid for biological manufacturing of oil processing byproduct protein resources.

The present application relates to the technical field of medical use, and particularly relates to a new use of gossypol acetic acid in regulating KCNQ5 potassium ion channel, especially to its application as a KCNQ5 potassium ion channel activator and in preparing related drugs. Through whole cell patch clamp experiment, it is found that gossypol acetic acid can significantly enhance KCNQ5 channel-mediated outward potassium current, slow the channel deactivation process, and make the conductance-voltage relationship curve move to the negative potential direction, which indicates that it can reduce the voltage threshold required for channel activation, enhance the KCNQ5 channel opening tendency and the stability of the open state. The present application provides an experimental basis for gossypol acetic acid as a KCNQ5 potassium ion channel activator, and provides a new candidate scheme for developing a drug for preventing and / or treating KCNQ5 function abnormality related diseases.