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Sustained release medicament of compound gossypol acetate

A technology of gossypol acetate and sustained release is applied in the field of medicaments for treating gynecological diseases, can solve the problem of not developing oral gossypol acetate preparations and the like, and achieve the effects of lasting effect, enhanced effectiveness and stable blood drug concentration

Active Publication Date: 2006-09-06
XIAN NORTH PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But those skilled in the art both at home and abroad do not develop the oral gossypol acetate preparation that meets the above-mentioned conditions at present

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0029] Example 1: Taking 1000 tablets as an example, the raw and auxiliary materials of the compound gossypol acetate slow-release medicament are weighed according to the following weight ratio:

[0030] Gossypol Acetate 12g Potassium Chloride 230g

[0031] Vitamin B 1 5.73g Vitamin B 6 5.73g

[0032] Hydroxypropyl Methyl Cellulose (HPMC) 15g Starch 65g

[0033] Magnesium stearate 8.3g

[0034] Gossypol acetate, potassium chloride, vitamin B 1 , Vitamin B 6 , mixed evenly with hydroxypropyl methylcellulose, granulated with 70% ethanol, dried, granulated, added with magnesium stearate, mixed evenly, then compressed by a tablet machine, coated, to obtain final product.

example 2

[0035] Example 2: Taking 1000 tablets as an example, take the raw and auxiliary materials of the compound gossypol acetate slow-release medicament according to the following weight ratio:

[0036] Gossypol Acetate 20g Potassium Chloride 250g

[0037] Vitamin B 1 10g Vitamin B 6 10g

[0038] Hydroxypropyl methylcellulose (HPMC) 26.7g starch 50g

[0039] Magnesium Stearate 9.2g

[0040] Preparation:

[0041] Gossypol acetate, potassium chloride, vitamin B 1 , Vitamin B 6 , mixed evenly with hydroxypropyl methylcellulose, granulated with 70% ethanol, dried, granulated, added with magnesium stearate, mixed evenly, then compressed by a tablet machine, coated, to obtain final product. 20 cases of uterine fibroids, 11 cases of endometriosis, and 15 cases of dysfunctional uterine bleeding were treated with the drug of Example 2. The treatment plan was to take 1 tablet of the above-mentioned medicament orally after dinner every day, and give continuous administra...

example 3

[0043] Example 3: Take the dosage of 1000 tablets as an example, take the raw and auxiliary materials of compound gossypol acetate sustained-release tablets according to the following weight ratio:

[0044] Gossypol Acetate 31g Potassium Chloride 387.5g

[0045] Vitamin B 1 15.5g Vitamin B 6 15.5g

[0046] Hydroxypropyl methylcellulose (HPMC) 11.3g starch 118g

[0047] Magnesium Stearate 14g

[0048] Preparation:

[0049] Gossypol acetate, potassium chloride, vitamin B 1 , Vitamin B 6 , mixed evenly with hydroxypropyl methylcellulose, granulated with 70% ethanol, dried, granulated, added with magnesium stearate, mixed evenly, then compressed by a tablet machine, coated, to obtain final product.

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PUM

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Abstract

This invention is about a medicament for gynaecological diseases therapy; specifically about a slow release agent and double-layer slow release medicament those contain gossypol acetate and other drugs. The gossypol acetate slow release medicament contains gossypol acetate, potassium chloride, vitamin B1, vitamin B6, hydropropyl methylcellulose, and other skeleton materials. While the double-layer slow release medicament is proportionally composed of gossypol acetate, potassium chloride, vitamin B1, vitamin B6, hydropropyl methylcellulose, and other skeleton materials; and its snap release layer is proportionally composed of gossypol acetate, crosslinked polyketals, and other disintegration agent.

Description

[0001] The invention relates to a medicament for treating gynecological diseases, in particular to a sustained-release agent containing gossypol acetate and other drugs and a double-layer sustained-release medicament. Background technique [0002] Gossypol is one of the main components of cottonseed. It is recorded in TCM literature that it has the effects of warming the kidney, tonifying deficiency and stopping bleeding. my country is a large cotton-producing country with rich sources of cottonseed. A large number of domestic and foreign experts have confirmed that gossypol is an effective and safe drug, which can block ovarian and endometrial steroid hormone receptors and treat uterine fibroids and endometrium. The treatment of heterotopia has a good effect. Xi'an North Pharmaceutical Co., Ltd. organized the declaration of compound gossypol acetate tablets based on the relevant literature of gossypol acetate and a large number of experimental and clinical studies. This variet...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61K9/22A61P15/00A61K31/51A61K31/4415A61K31/216
Inventor 刘德强李瑛刘倩
Owner XIAN NORTH PHARMA
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