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Pharmaceutical composition of cattail pollen or its extract and hawkthorn leaf or its extract

A technology of composition and extract, which is applied in the field of medicine to achieve the effects of improving cerebrovascular circulation, anti-platelet aggregation, and improving hemodynamics

Inactive Publication Date: 2008-04-16
SHANDONG XUANZHU PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no report on the use of the interaction between Puhuang or Puhuang extract and hawthor

Method used

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  • Pharmaceutical composition of cattail pollen or its extract and hawkthorn leaf or its extract
  • Pharmaceutical composition of cattail pollen or its extract and hawkthorn leaf or its extract
  • Pharmaceutical composition of cattail pollen or its extract and hawkthorn leaf or its extract

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0116] The preparation of embodiment 1 hawthorn leaf extract

[0117] 1, the preparation method of hawthorn leaf extract

[0118] Take hawthorn leaves, dry and crush them, add 60% ethanol to reflux and extract three times, each time for 1 hour, add 8 times the amount of ethanol, combine the extracts, filter, and recover the ethanol from the filtrate under reduced pressure until the relative density is 1.04-1.06 (60°C) After diluting with an equal amount of water, shake and extract with 1 / 2 times the amount of petroleum ether (60-90°C), discard the petroleum ether solution, shake and extract the aqueous layer with ethyl acetate, and depressurize the extract Recover ethyl acetate and concentrate to dryness, then add appropriate amount of water to dissolve, add to the treated polyamide column (30-60 mesh, wet packing with ethanol, pre-wash with appropriate amount of ethanol, then wash with water until no alcohol smell, set aside ), first eluted with 2 times column volume of wa...

Embodiment 2

[0135] The preparation of embodiment 2 Puhuang extract

[0136]1, the preparation method of Pollen extract

[0137] Take the medicinal material of Puhuang, add 70% ethanol to extract three times, and extract for 3 hours each time. Add alcohol 14 times the amount for the first and second times, add alcohol 10 times the amount for the third time. Combine the extracts, filter, recover the ethanol from the filtrate to a concentrated solution with a relative density of 1.04-1.06 (50°C), add an equal amount of water to dilute, mix well, refrigerate at 4°C for 24 hours, centrifuge, take the supernatant, and use an equal amount of Shake and extract petroleum ether for 2 times, discard the petroleum ether liquid, shake and extract the water liquid with an equal amount of water-saturated n-butanol for 3 times, combine the n-butanol extracts, concentrate to dryness, add a small amount of water to dissolve the residue, and go to AB -8 macroporous resin columns, eluting with water, 35%...

Embodiment 3

[0147] The preparation of embodiment 3PS tablet

[0148] Prescription one:

[0149] Hawthorn leaf extract 12g is equivalent to 0.5kg of the original medicinal material

[0150] Puhuang extract 24g is equivalent to 1kg of raw medicinal materials

[0151] 120g pregelatinized starch

[0152] Microcrystalline Cellulose 40g

[0153] Low-substituted hydroxypropyl cellulose 40g

[0154] 2% HPMC aqueous solution appropriate amount

[0155] Magnesium Stearate 6g

[0156] Carboxymethyl Starch Sodium 12g

[0157]

[0158] A total of 1000 tablets were prepared

[0159] Prescription two:

[0160] Hawthorn leaf extract 25g is equivalent to 1kg of the original medicinal material

[0161] Puhuang extract 24g is equivalent to 1kg of raw medicinal materials

[0162] 120g pregelatinized starch

[0163] Microcrystalline Cellulose 40g

[0164] Low-substituted hydroxypropyl cellulose 40g

[0165] 2% HPMC aqueous solution appropriate a...

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Abstract

The present invention relates to medical technique field, to disclose a medicinal composition of cattail pollen or its extraction and hawthorn leaves or its extraction, and its preparation method and application in preparing medicine for treating cardiovascular and cerebrovascular diseases and preparation containing the medicinal composition. Calculation according to the weight components, constitution of the raw materials used for preparing the medicinal composition containing the effective components are: cattail pollen 1000 to 10000, hawthorn leaves 500 to 10000, or are: cattail pollen extraction 20 to 400, hawthorn leaves 10 to 250. The medicinal composition can be prepared into clinic or pharmaceutical acceptable preparations, optimizing oral preparation or injection. The medicinal composition of the present invention has synergistic interaction, effect is increased greatly than using single single cattail pollen or its extraction and hawthorn leaves or their extractions. Exerting anti-myocardial ischemia together, increasing the blood flow of coronary artery, antiplatelet aggregaition, lowering blood pressure, improving blood flow dynamics, improving brain blood circulation, anti-anoxia and etc.

Description

[technical field] [0001] The present invention relates to a pharmaceutical composition of Puhuang or its extract and hawthorn leaf or its extract and its preparation method, its application in the preparation of medicines for treating cardiovascular and cerebrovascular diseases, and a preparation containing the pharmaceutical composition, belonging to the technical field of medicine . [Background technique] [0002] Cardiovascular and cerebrovascular diseases include coronary heart disease, angina pectoris, myocardial infarction, congestive pulmonary heart disease, ischemic encephalopathy, cerebral thrombosis, hypertension, hyperlipidemia, etc. The main cause of these diseases is that arteriosclerosis causes narrowing of the lumen and blockage of the pipeline, which leads to insufficient blood supply to the heart and brain, causing symptoms such as dizziness, dizziness, headache, and chest tightness. In severe cases, it can lead to stroke and myocardial infarction. Cardioce...

Claims

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Application Information

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IPC IPC(8): A61K36/88A61P9/10A61P9/12A61P7/02
Inventor 黄振华
Owner SHANDONG XUANZHU PHARMA TECH CO LTD
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