Medicinal composition for cardiovascular and cerebrovascular diseases

A composition and drug technology, applied in the field of medicine, to achieve the effects of scavenging free radicals, improving cerebrovascular circulation, and inhibiting lipid peroxidation

Inactive Publication Date: 2008-04-30
SHANDONG XUANZHU PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, using the interaction between Epimedium or Epimedium extract and Pueraria root or Pueraria root extract to prepare medicines for treating cardiovascular and cerebrovascular diseases, etc., has not been reported yet.

Method used

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  • Medicinal composition for cardiovascular and cerebrovascular diseases
  • Medicinal composition for cardiovascular and cerebrovascular diseases
  • Medicinal composition for cardiovascular and cerebrovascular diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0082] The preparation and assay of embodiment 1 epimedium extract

[0083] 1. Preparation of Epimedium Extract

[0084] Take 1000g of Epimedium medicinal material, crush it into medium powder, add 12 times the amount of 70% ethanol, soak for 12 hours, filter, and use the filtrate for later use; add 70% ethanol to heat and extract three times, each time for 1.5 hours, filter, and combine the filtrate , the filtrate was concentrated under reduced pressure to 1000ml, put on the treated D101 macroporous resin column, first eluted with 4L of distilled water, then eluted with 3L of 25% ethanol, and finally eluted with 15L of 70% ethanol, collected 70% ethanol for elution Liquid, recovery of ethanol under reduced pressure, vacuum drying, that is.

[0085] Three batches of Epimedium extract were prepared according to the above method, and the yields are shown in Table 5.

[0086] 2. Content Determination of Epimedium Extract

[0087] Determination of Total Flavonoids in Epimediu...

Embodiment 2

[0097] Preparation and content determination of embodiment 2 kudzu root extract

[0098] 1. Preparation of root extract

[0099] Take the Pueraria root medicinal material, crush it, add 70% ethanol to heat and reflux to extract twice, add 12 times the amount of alcohol for the first time, extract for 2 hours, add 10 times the amount of alcohol for the second time, extract for 1 hour, combine the extracts, filter, and filtrate Concentrate until there is no alcohol smell, filter, and elute with water and 70% ethanol respectively in the AB-8 macroporous resin that has been treated on the filtrate, and the elution volume is 4 times the volume of the column. Deliquify, recover ethanol, concentrate under reduced pressure to a relative density of 1.1-1.3 (50°C), and dry to obtain the product.

[0100] 2. Determination of Pueraria root extract content

[0101] Determination of Total Flavonoids in Pueraria Radix

[0102] Preparation of Reference Substance Solution Accurately weigh...

Embodiment 3

[0109] The preparation of embodiment 3YG tablet

[0110] Prescription one:

[0111] Epimedium extract 208g (equivalent to 8000g of the original medicinal material)

[0112] Pueraria root extract 168g (equivalent to 4000g of raw medicinal materials)

[0113] 120g pregelatinized starch

[0114] Microcrystalline Cellulose 40g

[0115] Low-substituted hydroxypropyl cellulose 40g

[0116] 2% HPMC aqueous solution appropriate amount

[0117] Magnesium Stearate 6g

[0118] Carboxymethyl Starch Sodium 12g

[0119]

[0120] A total of 1000 tablets were prepared

[0121] Prescription two:

[0122] Epimedium extract 13g (equivalent to 500g of raw material)

[0123] Pueraria root extract 21g (equivalent to 500g of raw medicinal materials)

[0124] 120g pregelatinized starch

[0125] Microcrystalline Cellulose 40g

[0126] Low-substituted hydroxypropyl cellulose 40g

[0127] 2% HPMC aqueous solution appropriate amount

...

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Abstract

The invention belongs to the field of medicine technique and discloses a medicament composition of barren wort or extract and kudzu root or extract, process for preparation of the medicament composition, application in preparing medicament for curing cardio-cerebrovascular disease, and medicament which contains the medicament composition. According to the part by weight, components of raw material medicine for preparing the medicament composition are as follows: barrel wort 250-8000 parts, kudzu root 125-2000 parts, or barrel wort extract 5-240 parts and kudzu root extract 3.5-100 parts, which can be prepared into any acceptable clinical or pharmaceutical dosage forms, and the optimal selection is oral medicament or injecting medicament. Two medicaments in the medicament composition of the invention have synergistic interaction. Compared with the independent usage of barren wort or extract and kudzu root or extract, the therapeutic effect is greatly enhanced. Two medicaments simultaneously increase blood flow in the coronary atery and improve blood flow mechanics and cerebrovascular circulation and have the functions of anti-myocardial ischemia, and anti-platelet aggregation and the like.

Description

[technical field] [0001] The present invention relates to a pharmaceutical composition of epimedium or its extract and kudzu root or its extract, its preparation method, its application in the preparation of medicines for treating cardiovascular and cerebrovascular diseases, and a preparation containing the pharmaceutical composition, belonging to the technical field of medicine . [Background technique] [0002] Cardiovascular and cerebrovascular diseases include coronary heart disease, angina pectoris, myocardial infarction, congestive pulmonary heart disease, ischemic encephalopathy, cerebral thrombosis, hypertension, hyperlipidemia, etc. The main cause of these diseases is that arteriosclerosis causes narrowing of the lumen and blockage of the pipeline, which leads to insufficient blood supply to the heart and brain, causing symptoms such as dizziness, dizziness, headache, and chest tightness. In severe cases, it can lead to stroke and myocardial infarction. Cardiocerebr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61P9/10A61P9/12A61P3/06
Inventor 黄振华
Owner SHANDONG XUANZHU PHARMA TECH CO LTD
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