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Novel compounds and applications thereof
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A compound, pentanediol technology, applied in the field of new compounds, can solve the problem of no pharmacological activity, and achieve the effects of excellent cardiovascular and cerebrovascular pharmacological activity, improvement of neurological symptoms, and inhibition of thrombosis
Inactive Publication Date: 2016-04-27
米文君
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And 2-(1R, 4S-pentanediol) benzoic acid, 2-(1R, 4R-pentanediol) benzoic acid and salts thereof do not show this pharmacological activity
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[0106] Oral administration was administered once a day for 3 consecutive days, and the thrombosis model group was given the same amount of vehicle. Surgery was performed after the la...
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Abstract
The invention relates to novel compounds and applications thereof. The novel compounds are specifically 2-(1S,4S-pentanediol)benzoic acid, 2-(1S,4R-pentanediol)benzoic acid, 2-(1S,4S-pentanediol)benzoate, and 2-(1S,4R-pentanediol)benzoate. The invention also relates to the applications of the novel compounds in preventing and treating cardio-cerebral ischemic diseases, ameliorating cardio-cerebral circulation disorders, resisting thrombosis, and the like. In animal pharmacodynamics model tests, the novel compounds provided by the invention show excellent protection effects upon brain tissue damage caused by middle cerebral arteryocclusion. With the novel compound, neurological symptoms of middle cerebral arterythrombosis model rats can be substantially ameliorated, infarct sizes can be substantially reduced, and rat artery-vein bypass thrombosis can be substantially inhibited. Therefore, the compounds provided by the invention assists in effectively inhibiting thrombosis, and have good prevention and treatment effects against cardio-cerebral ischemic diseases.
Description
technical field [0001] The present invention relates to new compounds and uses thereof, specifically, the present invention relates to 2-(1S, 4S-pentanediol) benzoic acid, 2-(1S, 4R-pentanediol) benzoic acid, 2-(1S, 4S- Pentylene glycol) benzoate, 2-(1S, 4R-pentanediol) benzoate, also relates to the use of such compounds in the prevention and treatment of cardio-cerebral ischemic diseases and improving cardio-cerebral circulation disorders, antithrombotic etc. aspects of application. Background technique [0002] Cerebral ischemic disease has the characteristics of high morbidity, disability and mortality. It is a common and frequently-occurring disease that endangers human life and health. Therefore, the search for anti-ischemic drugs has attracted widespread attention from scholars at home and abroad. [0003] Butylphthalide, also known as apigenin, was originally found in celery seeds. Its pharmacodynamic characteristics cover many aspects: 1. It can improve the energy m...
Claims
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Application Information
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