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Medicine composition containing dehydrogenated corydaline as well as preparation method and measurement method

A technology of dehydrofumarine and a composition, applied in the field of medicine, can solve problems such as undiscovered and undiscovered dehydrofumarine, and achieve the effects of short production cycle, reducing the degree of myocardial infarction, and prolonging anti-myocardial ischemia.

Inactive Publication Date: 2012-06-27
YANGTZE DELTA REGION INST OF TSINGHUA UNIV ZHEJIANG
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Before the completion of the present invention, there was no research report on dehydrodrycardine and its composition for anti-myocardial ischemia and hypoxia resistance, nor did it find that dehydrodrytidine and its main ingredients containing african tetrandrine and 13-methyl dehydrocorydalis Application of the composition of alkali, dehydrocorydaline, palmatine, etc. in the treatment of anti-myocardial ischemia and hypoxia-resistant drugs

Method used

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  • Medicine composition containing dehydrogenated corydaline as well as preparation method and measurement method
  • Medicine composition containing dehydrogenated corydaline as well as preparation method and measurement method
  • Medicine composition containing dehydrogenated corydaline as well as preparation method and measurement method

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Experimental program
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preparation example Construction

[0025] Preparation of the reference substance solution: Accurately weigh an appropriate amount of the dehydrodrycodine reference substance, and dissolve it in methanol to make a reference substance solution with a concentration of 126.88 μg / mL;

[0026] Preparation of the test solution: take 10 mg of the composition, accurately weigh it, dissolve it with 80% methanol and set the volume in a 10mL measuring bottle, as the test solution;

[0027] Determination method: Precisely draw 10 μL each of the reference substance solution and the test solution, inject it into a liquid chromatograph, measure it, and obtain it.

[0028] A method for determining the total alkaloids of the quaternary ammonium corydalis of the pharmaceutical composition containing dehydrodrytidine as described above, which utilizes the following ultraviolet colorimetric method for determination, comprising:

[0029] Preparation of the reference substance solution: Take an appropriate amount of dehydrodrycodine,...

Embodiment

[0033] 1. Extraction and preparation of compositions containing dehydrodrycardine

[0034]Rhizoma Corydalis, pulverized, added 14 times the amount of 80% ethanol to reflux and extracted 3 times (6 times, 4 times, 4 times), each time for 4 hours, combined the extracts, filtered to remove the dregs, and recovered the ethanol from the filtrate until it had no alcohol smell. The medicinal solution is properly diluted with deionized water, passed through the X-5 macroporous adsorption resin, and the medicinal solution is adsorbed by the resin column at a flow rate of 2 ml / min. After the adsorption is completed, the non-adsorbed impurities are first washed away with 2% ammonia solution. Then elute with 50% ethanol solution, collect the alcohol eluate, concentrate the eluate under reduced pressure, and dry it in vacuum below 60°C. Compositions of dehydrodrytidine. This composition contains 57.40% of quaternary ammonium total alkaloids, including 14.05% of dehydrodrylamine, 4.06% of ...

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Abstract

The invention relates to a medicine composition containing dehydrogenated corydaline as well as a preparation method and a measurement method. The medicine composition is a composition which is mainly prepared by a method for extracting a medicinal material of corydalis tuber through the thermal refluxing of ethanol and purifying the corydalis tuber by macroporous adsorptive resin, and comprises dehydrogenated corydaline, total quaternary ammonium hydroxide, columbamine, 13-methyldehydrocorydalmine, dehydrocorybulbine and palmatine, wherein the content of the dehydrogenated corydaline, which is measured by using a high-efficiency liquid chromatography method, is not lower than 10 percent; the content of the total quaternary ammonium hydroxide in the composition, which is calculated according to the dehydrogenated corydaline, is not lower than 50 percent; and the measurement method comprises a measurement method to the dehydrogenated corydaline and a measurement method to the total quaternary ammonium hydroxide of the corydalis tuber. The medicine composition containing the dehydrogenated corydaline as well as the preparation method and the measurement method have the characteristics of simple production process, short production period, high safety, no pollution to the environment, low cost, high yield and the like, and are especially suitable for industrialized mass production; and the medicine composition containing the dehydrogenated corydaline can be used for lowering the degree of myocardial infarction and has the functions of obviously resisting myocardial ischemia and obviously prolonging the anoxia-proof time of a rat.

Description

technical field [0001] The present invention relates to a kind of anti-myocardial ischemia and hypoxia-resistant pharmaceutical composition, specifically, it is dehydrodrycardine and mainly contains African tetrandrine, 13-methyl dehydrogenation cordydamine, dehydrogenation cordydine The application of bulbine, palmatine, etc. in the preparation of anti-myocardial ischemia and hypoxia-resistant drugs belongs to the field of medical technology. Background technique [0002] Corydalis yanhusuo (Corydalis yanhusuo W.T.Wang), commonly known as Yuanhu, was first recorded in "Supplements to Materia Medica". It has the effects of promoting qi and relieving pain, promoting blood circulation and removing blood stasis. The chemical components of Corydalis are mainly alkaloids, which can be divided into tertiary amine bases and quaternary ammonium bases according to the nature of its amino nitrogen. So far, most of the alkaloids found in its tubers are tertiary amine bases. , while th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4375A61P9/10G01N30/02G01N30/06G01N21/31
Inventor 刑东明石钺孟凡国胡卫江李海龙周海梦
Owner YANGTZE DELTA REGION INST OF TSINGHUA UNIV ZHEJIANG
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