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Nauclea officinalis extract and preparation and use thereof

A kind of extract, the technology of bile wood, applied in the field of bile wood extract

Active Publication Date: 2013-01-09
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the prior art, there is no report of extracting isovinca lactam from B. chinensis, further refining it to make its content reach more than 90%, and being used to prepare anti-inflammatory, antibacterial, anti-viral, and anti-high fever drugs.

Method used

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  • Nauclea officinalis extract and preparation and use thereof
  • Nauclea officinalis extract and preparation and use thereof
  • Nauclea officinalis extract and preparation and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0118] Example 1. A gallwood extract, its extraction steps are as follows,

[0119] (1) Take the flaky heartwood, branches, trunk, bark or leaves of Rubiaceae Ebony genus, dry, pulverize, extract with alcohol-water mixed solution or organic solvent, combine the extracts, refrigerate overnight, filter, and recover alcohol water Mixed solution or organic solvent; then add to water or alkaline solution, stir, stand still, then adjust the pH to 8 with acidic solution, refrigerate, stand still, filter, put the filtrate separately, take the precipitate and add it to the alkaline solution , stir to dissolve, let stand, and then adjust the pH to 8 with an acidic solution, refrigerate, stand, filter, discard the filter residue, and combine the filtrate with the previous filtrate to obtain the crude extract solution;

[0120] or,

[0121] (1) Take the flaky heartwood, branches, trunk, bark or leaves of Rubiaceae Ebony genus, dry, grind, extract with water or alkaline aqueous solution...

Embodiment 2

[0125] Example 2. A gallwood extract, its extraction steps are as follows,

[0126] (1) Take the flaky heartwood, branches, trunk, bark or leaves of Rubiaceae Ebony genus, dry, pulverize, extract with alcohol-water mixed solution or organic solvent, combine the extracts, refrigerate overnight, filter, and recover alcohol water Mix solution or organic solvent; then add to water or alkaline solution, stir, stand still, then adjust pH to 4 with acidic solution, refrigerate, stand still, filter, put the filtrate separately, take the precipitate and add it to the alkaline solution , stir to dissolve, let stand, then adjust the pH to 4 with an acidic solution, refrigerate, stand, filter, discard the filter residue, and combine the filtrate with the previously separated filtrate to obtain the crude extract solution;

[0127] or,

[0128] (1) Take the flaky heartwood, branches, trunk, bark or leaves of Rubiaceae Ebony genus, dry, grind, extract with water or alkaline aqueous soluti...

Embodiment 3

[0132] Example 3. A gallwood extract, its extraction steps are as follows,

[0133] (1) Take the flaky heartwood, branches, trunk, bark or leaves of Rubiaceae Ebony genus, dry, pulverize, extract with alcohol-water mixed solution or organic solvent, combine the extracts, refrigerate overnight, filter, and recover alcohol water Mix solution or organic solvent; then add to water or alkaline solution, stir, stand still, then adjust pH to 6 with acidic solution, refrigerate, stand still, filter, put the filtrate separately, take the precipitate and add it to the alkaline solution , stir to dissolve, let stand, and then adjust the pH to 6 with an acidic solution, refrigerate, stand, filter, discard the filter residue, and combine the filtrate with the previous filtrate to obtain the crude extract solution;

[0134] or,

[0135] (1) Take the flaky heartwood, branches, trunk, bark or leaves of Rubiaceae Ebony genus, dry, grind, extract with water or alkaline aqueous solution, refr...

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PUM

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Abstract

The invention relates to a medicinal fatheadtree extractive, which is extracted from the plate-typed heartwood, branches, trunks, barks or leaves of rubiaceae nauclea medicinal fatheadtree; the obtained medicinal fatheadtree extractive with vincoside-lactam as the principle component can used for preparing the medicines of antisepsis, antivirus, antiphlogosis or anti-hyperthermia. The invention further relates to a medicinal fatheadtree extractive preparation.

Description

technical field [0001] The present invention relates to an extract using Chinese herbal medicine as a raw material, in particular to an extract of birchwood; the invention also relates to a preparation and a medical application of the biloba extract. Background technique [0002] Isovincosidelactam is an indole alkaloid glycoside, its English name is Isovincosidelactone; Strictosamide; its molecular formula and molecular weight are C 26 h 30 N 2 o 8 ; 498.20; the structural formula is as follows: [0003] [0004] Isovinblastam is found in plants of Rubiaceae Ebony, especially in Rubiaceae Ebony (Nauclea officinalis Pierre ex Pitard), which is contained in its branches, trunks, bark and leaves. the ingredient. However, in the prior art, there is no report of extracting isovinca lactam from B. japonica and further refining the content to over 90% for the preparation of anti-inflammatory, anti-bacterial, anti-viral and anti-high fever drugs. Contents of the invention...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/74A61P31/04A61P31/12A61P29/00C07D493/22A61K135/00A61K127/00
Inventor 肖伟李明慧丁岗王成生孙世顷曹亮朱华荣
Owner JIANGSU KANION PHARMA CO LTD
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