A kind of red yeast rice wine with the function of lowering blood pressure

A red yeast rice wine and blood pressure lowering technology, applied in the field of red yeast rice rice wine, can solve the problems of high random factors, difficult strain screening, low survival rate, etc., and achieve the effect of increasing added value

Inactive Publication Date: 2011-12-07
义乌市丹溪酒业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In 1979, Professor Yuan Tengzhang of Japan Agricultural University, based on Mr. Zhu Danxi's TCM theory records, revealed that red yeast rice has the effect of promoting blood circulation, and found that the products fermented with red yeast rice have the effects of lowering blood fat, blood pressure, and blood sugar on the human body; 1987 Kohama et al. isolated GABA and acetylcholine from red yeast rice in 2010 and have the effect of lowering blood pressure. Chinese patent application (02158370.6) Monascus mutant strain and its use in the preparation of active fermentation products for lowering blood pressure. Although it has screened GABA content is higher, Monascus mutant strain with low citrinin content and related to its cultivation method, pharmaceutical composition and food additive, but the screening of the strain is difficult, and the survival rate after mutation is low, and the random factor is high; in addition, from the patent application document It is impossible to know whether the GABA in Monascus or its fermentation product is inactivated by temperature, pH value and other factors, thus losing the medicinal property of treating hypertension

Method used

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  • A kind of red yeast rice wine with the function of lowering blood pressure
  • A kind of red yeast rice wine with the function of lowering blood pressure
  • A kind of red yeast rice wine with the function of lowering blood pressure

Examples

Experimental program
Comparison scheme
Effect test

manufacture example 1

[0051] Take Danxi-1 (Monascus red strain Danxi-1), under aseptic conditions (sterile room or ultra-clean workbench), pick a small amount of bacteria by inoculation, transfer to sterilized Place it in an incubator at 25°C±1°C for activation and culture for 96 hours. Take out the activated strains for 96 hours, insert the activated strains into the sterilized first-grade solid maltose agar medium in the same way under aseptic conditions, and cultivate them at 25°C±1°C for 96 hours, which is Danxi-No. 1 first-class seed.

[0052] Adopt 500 milliliter glass triangular flasks, fill 100 milliliters of prepared liquid maltose culture medium, sterilize at 15 pounds for 30 minutes and set aside. Take Danxi No. 1 primary seeds and inoculate them in 500 ml glass triangular flasks containing 100 ml of liquid maltose medium under sterile conditions. After culturing on a shaker at 25°C±1°C for 96 hours, it was used as the secondary seed liquid for red yeast fermentation.

manufacture example 2

[0054] Take Danxi-3 (Monascus strain Danxi-3), under aseptic conditions (sterile room or ultra-clean workbench), pick a little strain by inoculation, transfer to the sterilized Place the solid maltose agar culture dish in an incubator at 25°C±1°C for 168 hours of activation. Take out the activated strains for 168 hours, insert the activated strains into the sterilized first-grade solid maltose agar medium in the same way under aseptic conditions, and cultivate them at 25°C±1°C for 168 hours, which is Danxi-No. 3 first-class seed.

[0055] Adopt 500 milliliter glass triangular flasks, fill 100 milliliters of prepared liquid maltose culture medium, sterilize at 15 pounds for 30 minutes and set aside. Take Danxi No. 3 primary seeds and inoculate them in 500 ml glass triangular flasks containing 100 ml of liquid maltose medium under sterile conditions. After 168 hours of shaker culture at 25°C±1°C, it was used as the secondary seed liquid for red yeast fermentation.

Embodiment 1

[0057] Soak the early indica rice used for making koji and steam it, then add Danxi No. 1 as the secondary seed liquid in the above manufacturing example 1 into the early indica rice, stir and ferment evenly for 5 days to make red koji, and dry the above-mentioned red koji Standby; take red koji distiller's grains and rice skin, add red koji, then add water and mix well, and ferment for 200 hours at a temperature of 25°C and a pH value of 6.0 to make functional red koji distiller's grains; wherein the red koji distiller's grains , The weight ratio of rice skin and red yeast rice is: 2.0:1.0:0.11; the weight ratio of the above three raw materials and water is 100:150; select organic glutinous rice as raw material, add pure water to soak for 30 hours, so that the raw material can fully absorb water 10 minutes after the infiltrated raw materials are evenly steamed, in the above raw materials, add the above-mentioned functional red yeast distiller's grains which account for 20% by ...

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Abstract

The invention relates to a red yeast rice wine with the function of lowering blood pressure; the red yeast rice rice wine is prepared by the following method: glutinous rice is used as a raw material, after steaming, the wine yeast made by adding red yeast rice and its auxiliary materials is 10% by weight of the raw material % to 20% of the functional red koji distiller's grains are firstly fermented, then fermented, and then squeezed to make red koji rice wine with the function of lowering blood pressure, and the red koji distiller's grains are recovered. The present invention makes full use of the supplementary material of red yeast rice wine - red yeast rice wine grains, thereby increases its added value, prepares the red yeast rice yellow rice wine with the function of lowering blood pressure with higher GABA content; Blood pressure can achieve unexpected results, and it has the function of assisting in lowering blood pressure.

Description

technical field [0001] The invention relates to a metabolite of red yeast rice, in particular to a red yeast rice wine with the function of lowering blood pressure. Background technique [0002] Hypertension is a common disease with elevated blood pressure in the systemic circulation as the main clinical manifestation. It often involves blood vessels, especially small and small arteries throughout the body, and important organs such as the heart, kidney, and brain, and often causes stroke and chronic cardiac insufficiency. , renal failure and other complications, the existing antihypertensive drugs can be divided into: (1) diuretics, hydrochlorothiazide, etc., but the use of these drugs will cause adverse reactions such as aggravating hyperlipidemia and reducing glucose tolerance; (2) ) Angiotensin I-converting enzyme inhibitors and angiotensin II receptor blockers, captopril, losartan, etc., but the use of these drugs may cause adverse reactions such as hypotension, cough, ...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): C12G3/02C12R1/66
Inventor陈豪锋朱丹华朱兰琴薛临生朱睦元陈铭
Owner义乌市丹溪酒业有限公司