Unlock instant, AI-driven research and patent intelligence for your innovation.

Synthesis of 1-isobutyl-2-methyl imidazole

A technology of methyl imidazole and synthesis method, applied in directions such as organic chemistry, can solve the problem of high cost, and achieve the effects of low cost, high yield and improved yield

Active Publication Date: 2009-04-08
ABA CHEM SHANGHAI
View PDF0 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

), but the cost is higher

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] According to the mol ratio of the raw material material that present embodiment adopts is 2-methylimidazole: chloroisobutane=1: 1.2, the specific operation steps of this method are as follows:

[0015] Add 25ml of triethylamine to 100ml of toluene, add 12.3g of 2-methylimidazole, heat to 60~65°C, after dissolving, slowly add 16.7g of chloroisobutane dropwise at this temperature, after the dropwise addition is completed Keep warm at 60-65°C for 3 hours, slowly heat up to 100-110°C after 3 hours, and keep warm at this temperature for 5 hours. After the heat preservation is completed, cool to below 10°C, filter, distill the filtrate, collect 96-98°C (4.5 mmHg) fraction 13g, which is 1-isobutyl-2-methylimidazole. Based on 2-methylimidazole, the molar yield of this method is 63%.

Embodiment 2

[0017] Add 6 grams of sodium hydroxide, 0.1 grams of phase transfer catalyst tetrabutylammonium iodide to 100 milliliters of toluene, add 12.3 grams of 2-methylimidazole, heat to 60-65 ° C, slowly drop 16.7 grams of chlorine at this temperature Substituted isobutane, after the dropwise addition, keep warm at 60-65°C for 3 hours, slowly heat up to 100-110°C after 3 hours, and keep warm at this temperature for 5 hours, cool to below 10°C after the heat preservation is completed, filter, The filtrate was distilled, and 14.3 grams of distillate at 96-98°C (4.5 mmHg) was collected, which was 1-isobutyl-2-methylimidazole. Based on 2-methylimidazole, the molar yield of this method is 69%.

Embodiment 3

[0019] Add 6 grams of sodium hydroxide and 12.3 grams of 2-methylimidazole into 100 milliliters of DMF, heat to 50-55 ° C, and keep it warm for 1 hour. After the heat preservation is completed, slowly add 16.7 grams of chloroisobutane dropwise at this temperature After the dropwise addition, keep it warm at 60-65°C for 3 hours, slowly raise the temperature to 100-110°C after 3 hours, and keep it at this temperature for 3 hours. After the heat preservation is completed, cool to below 10°C and filter. 15.7 grams of distillate at 98°C (4.5mmHg) is 1-isobutyl-2-methylimidazole. Based on 2-methylimidazole, the molar yield of this method is 75.8%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a method for synthesizing 1-isobutyl-2-methylimidazole. 2-methylimidazole and isobutyl chloride are subjected to substitution reaction in the presence of solvent and an acid-binding agent to obtain the 1-isobutyl-2-methylimidazole, wherein the temperature of the substitution reaction is between 50 and 110 DEG C; and the mol ratio of the 2-methylimidazole to the isobutyl chloride is between 1:1.1 and 1:1.5. The method has the advantages of easily-obtained raw materials, high yield and low cost.

Description

technical field [0001] The invention belongs to the field of organic synthesis, in particular to a method for synthesizing 1-isobutyl-2-methylimidazole. Background technique [0002] 1-isobutyl-2-methylimidazole is an important coating additive and pharmaceutical intermediate. Literature does not yet have the report of this compound synthesis, and the synthesis of similar compound is mainly prepared by 2-methylimidazole and iodoalkane, although this method has higher yield (in terms of 2-methylimidazole, molar yield 70-90%.), but the cost is higher. Contents of the invention [0003] The technical problem to be solved by the present invention is to provide a synthetic method of 1-isobutyl-2-methylimidazole with readily available raw materials, high yield and low cost. [0004] In order to solve the above technical problems, the present invention takes the following technical solutions: [0005] A kind of synthetic method of 1-isobutyl-2-methylimidazole, by the substitut...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07D233/58
Inventor 高兴安林靖蔡彤
Owner ABA CHEM SHANGHAI
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com