Pu'er tea and application of preparation thereof in preventing and treating pestis

Abstract

The invention provides application of Pu'er tea and Pu'er tea preparation in preventing and treating plague, namely the Pu'er tea and the Pu'er tea preparation can inhibit the activity of protein tyrosine phosphatase of Yersinia outer membrane protein H - YopH in vitro. The outer membrane protein H in Yersinia is an only protein with the activity of the protein tyrosine phosphatase, can perform dephosphorylation on certain proteins of eukaryotic cells, not only damages the cytoskeleton and has antiphagocytic function but also can inhibit PI-3 channels so as to inhibit T lymphopoiesis, and is an important factor for the Yersinia to escape innate immunological response of hosts. Therefore, diseases caused by the Yersinia can be prevented and treated by inhibiting the activity of the protein tyrosine phosphatase of the Yersinia outer membrane protein H - the YopH, and a Pu'er tea effective inhibitor sieved by taking the Yersinia outer membrane protein H - the YopH as a target provides a novel method and novel concept for prevention and treatment of plague.

Description

technical field [0001] The invention relates to the application of Pu'er tea and its preparation in treating plague, and belongs to the technical field of medical application of substances. Background technique [0002] Plague is a severe zoonotic infectious disease caused by Yersinia pestis. Due to its acute onset, rapid spread, strong infectivity, and high fatality rate, it is defined as a frontier quarantine infectious disease by the World Health Organization, and is a Class A infectious disease stipulated in the "Law of the People's Republic of China on the Prevention and Control of Infectious Diseases". The anthrax spore mailing incident in the United States in 2001 drew worldwide attention to the threat of biological weapons. If Yersinia pestis is used in terrorist weapons and large-scale destructive war equipment, it will definitely become the preferred biological weapon of international terrorists, and thus has become one of the factors threatening world peace. Sin...

AI Technical Summary

Problems solved by technology

[0008] Studies have shown that although the cloning and expression of Yersinia pestis outer membrane protein Yops has been completed in China, there is a lack of targeted research on Yersinia pestis outer membrane protein H (YopH), and the screening of YopH inhibitors remains blank. Level

Although effective inhibitors of YopH have been screened from various compounds in foreign countries, they are difficult to promote due to the difficulty in obtaining materials, high cost, and large side effects. They only stay in the research on the mechanism and have not yet developed effective drugs for the treatment of plague.

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