Tiny vein injection drug delivery system on body surface of experimental animal

A technology of experimental animals and drug delivery devices, which is applied in the fields of medical science and veterinary equipment, etc., can solve the problems of experimental mice not being fixed well, thick needles, and needles piercing the blood vessel wall, etc. accurate effect

Inactive Publication Date: 2010-02-03
DALIAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When using this method to operate, the experimental mice cannot be fixed well, and the experimental animals are always in a state of struggle, which often leads to failure to insert the needle or the needle punctures the blood vessel after the animal struggles, resulting in the failure of the experiment
In addition, when using this method for tail vein injection, because the tail vein blood vessels of mice are relatively small and difficult to fill, the needle insertion is inaccurate, or the resistance during injection after needle insertion is relatively high, resulting in local swelling and whitening, and the injection fails. low rate
[0004] Patent CN: 200810018231 Use a special rod clamp to fix the hand shape of the operator when injecting the tail vei...

Method used

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  • Tiny vein injection drug delivery system on body surface of experimental animal
  • Tiny vein injection drug delivery system on body surface of experimental animal
  • Tiny vein injection drug delivery system on body surface of experimental animal

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Mouse tail vein injection administration:

[0025] Such as figure 1 As shown, the experimental animal body surface micro-venous injection drug delivery device is composed of an experimental animal fixed compartment 5, a simple desktop magnifying glass, a blood vessel clip 7 and a syringe 1 with an ultrafine injection needle 2. The experimental animal fixed compartment 5 is equipped with a drawable The cylindrical container for lifting the partition plate 4 and the fixed compartment cover 9 for the experimental animal, the slot for extracting the partition plate 4 is arranged on the fixed compartment 5 for the experimental animal, and the tail hole 6 for the experimental animal is set in the center of the fixed compartment cover 9 for the experimental animal; The simple desktop magnifying glass is composed of a magnifying glass 3 and a magnifying glass bracket 8, the magnifying glass 3 has a magnification of more than 40 times, the magnifying glass bracket 8 supports the...

Embodiment 2

[0031] Rat tail vein injection administration:

[0032] The specific embodiment is the same as in Example 1, except that the experimental animal fixed compartment 5 and the experimental animal fixed compartment cover 9 of the mouse are replaced with the experimental animal fixed compartment 5 and the experimental animal fixed compartment cover 9 of the rat.

Embodiment 3

[0034] Subcutaneous injection of mouse paw:

[0035] Expose the sole of the mouse’s foot, select the plantar vein of the foot under a magnifying glass, clamp the proximal end of the plantar vein of the mouse with a blood vessel clip 7, accurately locate the plantar vein of the mouse under the magnifying glass 3 of a simple desktop magnifying glass, and then use a A syringe 1 with an ultra-fine injection needle 2 having a diameter of 0.2 mm was injected into the plantar vein of the mouse.

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Abstract

The invention relates to a drug delivery system for experimental animals, in particular to a tiny vein injection drug delivery system on body surfaces of experimental animals. The system comprises a fixed chamber 5 for experimental animals, a simple desk type magnifying glass, a vascular clamp 7 and an injector 1 with a superfine injection needle 2, wherein the fixed chamber 5 for experimental animals fixes experimental animals; the vascular clamp 7 is clamped above injection blood vessel; the injector 1 is connected with the superfine injection needle 2; the simple desk type magnifying glassis arranged above vein injection operation, and the injection can be carried out; and component parts of the device can be used solely or be in arbitrarily combined use according to actual operation requirement. The invention has the beneficial effect that the tiny vein injection process of experimental animals is more accurate, efficient, convenient and fast.

Description

Technical field [0001] The patent of the present invention relates to a drug delivery device for experimental animals, in particular to a drug delivery device for micro-vein injection on the body surface of experimental animals. Background technique [0002] Microvenous administration on the body surface is a commonly used method of drug administration in experimental animals, but due to its high technical difficulty, the success rate in actual operation is very low, especially in the long-term administration process, often resulting in failure of the entire experiment due to the failure of the administration operation. Finish. [0003] At present, the microvenous administration method of experimental animals is mostly manually operated. The traditional operation process is to place the mouse in an upside-down beaker, expose the tail of the mouse to the outside of the beaker, and inject the drug into the tail vein of the mouse with a 1 ml syringe. When using this method to ...

Claims

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Application Information

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IPC IPC(8): A61D7/00
Inventor 王惠国冯宝民关鑫朱允昭匡艳林
Owner DALIAN UNIV
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