Process for separating and purifying special component specnuezhenide of glossy privet fruit

A technique for separation and purification of special privet glycosides, which can be used in organic chemistry, chemical instruments and methods, preparation of sugar derivatives, etc., and can solve problems such as lack of specificity

Inactive Publication Date: 2010-05-12
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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Problems solved by technology

[0005] The current pharmacopoeia of the People's Republic of China contains oleanolic acid as an ingredient in TLC identification and content determination under the Chinese medicinal material Ligustrum lucidum. Since this ingredient is contained in many medicinal materials, it lacks specificity

Method used

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  • Process for separating and purifying special component specnuezhenide of glossy privet fruit
  • Process for separating and purifying special component specnuezhenide of glossy privet fruit
  • Process for separating and purifying special component specnuezhenide of glossy privet fruit

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Embodiment Construction

[0009] Take Ligustrum lucidum medicinal material and add ethanol to heat and reflux to extract three times, filter, recover under reduced pressure to obtain ethanol extract, dilute with water, extract with petroleum ether, chloroform, and n-butanol in sequence to obtain extract, apply macroporous resin, wash with water and be colorless , and then eluted with 20% to 90% ethanol, the eluents were combined, and then purified by a reversed-phase silica gel column and a reversed-phase silica gel chromatography column to obtain the obtained product.

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Abstract

The invention relates to a process for separating and purifying a special component specnuezhenide of glossy privet fruit, which is a dry ripe fruit of Ligustum lucidum Ait recorded in the books of Chinese Pharmacopoeia in all ages. The current Chinese Pharmacopoeias shows that the component under the item of the traditional Chinese medicament glossy privet fruit is oleanolic acid after identifying the film and measuring the content, and the component is contained in different medical materials, so it is not special. Through research, the specnuezhenide belongs to secoiridoid glycoside compounds, and is the special component of the glossy privet fruit, so the specnuezhenide can be used as an important index for controlling the quality of the glossy privet fruit. The special component has been recorded under the item of the traditional Chinese medicament glossy privet fruit in Chinese Pharmacopoeias 2010 Edition, and is about to be issued and implemented as the content of Chinese Pharmacopoeia. The process for separating and purifying the specnuezhenide is invented by researchers of Institute of Chinese Materia Medica, China Academy of Chinese Academy of Sciences, and is prepared by ethanol extraction, macroporous absorbent resin separation, and reverse silica gel column purification.

Description

1. Technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a process for separating and purifying a specific component privet privet glycoside from the fruit of the traditional Chinese medicine Ligustrum lucidum. 2. Background technology [0002] Ligustrum lucidum is the dry ripe fruit of Ligustum lucidum Ait of Oleaceae plant privet. According to the records in "Historical Records Hanshu": "Drugs commonly used in the Qin and Western Han Dynasties include the following varieties: Herbal medicines: Poria cocos, rabbit silk, lotus root, Qian, privet..." 48 kinds of medicines recorded in "Hanshu" Among them, 19 species including Ligustrum lucidum were listed as "prolonging years" by the "Shen Nong's Materia Medica" written after the Eastern Han Dynasty. Herbs are recorded in subsequent editions, and Ligustrum lucidum is also included in the "Chinese Pharmacopoeia" in successive editions. Ligustrum luci...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/04C07H1/08
Inventor 李曼玲康琛胡魁伟仝会娟
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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