Extract of Albizia chinensis (Osbeck) Merr, preparation method, combination and purpose thereof

An extract and technology of jacaranda tree, applied in the field of jacaranda tree extract, its preparation and its composition and application, can solve the problems of chemical composition and biological activity of jacaranda bark that have not been seen yet, and achieve fast onset and curative effect of the drug Significant, low effective dose effect

Active Publication Date: 2010-07-07
INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, there have been no reports on other chemical constituents and biological activities of Jacaranda bark

Method used

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  • Extract of Albizia chinensis (Osbeck) Merr, preparation method, combination and purpose thereof
  • Extract of Albizia chinensis (Osbeck) Merr, preparation method, combination and purpose thereof
  • Extract of Albizia chinensis (Osbeck) Merr, preparation method, combination and purpose thereof

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Embodiment 1

[0069] The preparation method of embodiment 1 Jacaranda extract

[0070] Weigh 2.5Kg of jacaranda stem bark, reflux three times with 8 times the volume of 70% ethanol, each time for 2.5 hours; the extract is concentrated under reduced pressure to obtain 475g of extract (remembered as SJ1), suspended in 2 times the volume of water, etc. volume of sherwood oil, ethyl acetate, and n-butanol were extracted three times respectively, concentrated under reduced pressure and evaporated to dryness, and obtained respectively the extract 2.7g of sherwood oil, the extract 26.5g of ethyl acetate, and the extract 104.5g of n-butanol ( Record as SJ2), 250g of water extract. Separate the n-butanol extract on a polyamide column; dissolve the n-butanol extract in water, filter (about 95.0g) and add it to a 1250g 30-60 mesh polyamide column, use 6L of water, 6L30 % ethanol, 7L of 60% ethanol for gradient elution, and each part was concentrated to dryness to obtain 18.1 g of water extract, 8.7 g...

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Abstract

The invention relates to the application of Albizia chinensis (Osbeck) Merr in the preparation of calming hypnotic medicine, an extract of the Albizia chinensis (Osbeck) Merr, a preparation method of the extract, and a medicine combination containing the extract. The stem skin of the Albizia chinensis (Osbeck) Merr is dried, crushed, extracted, concentrated and purified, so as to obtain the extract with the calming hypnotic function. Effective components include catechin compounds. Pharmacological tests show that the extract has the characteristics of low effective dose, quick medicinal effect exerting, obvious curative effect, good safety and high reliability.

Description

technical field [0001] The present invention relates to the application of Albizia chinensis (Osbeck) Merr. in the preparation of sedative and hypnotic drugs, and the extract of the jacaranda tree. Specifically, it relates to an extract with sedative and hypnotic effects extracted from the bark of the jacaranda tree. The preparation method of the extract, the pharmaceutical composition containing the extract, and the use of the extract and the pharmaceutical composition as medicine, especially the application of preparing sedative and hypnotic drugs. Background technique [0002] Insomnia is one of the most common diseases clinically, and the incidence rate is relatively high. Statistics show that the prevalence rate of insomnia is about 30-35%, and the quite serious ones account for about 10-15% among insomnia patients. Insomnia seriously affects people's life, work and physical and mental health. At present, the sedative-hypnotics used clinically are mainly barbiturates, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61P25/20A61K135/00
Inventor 庾石山张建军农华刘锐屈晶徐嵩
Owner INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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